The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15013: Voltage-gated potassium channel beta subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
9 P62482 (/ISS) P63143 (/ISS) Q13303 (/ISS) Q14722 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PTM5 (/ISS) Q9XT31 (/ISS)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
8 P62482 (/ISS) P63143 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PTM5 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
6 P63143 (/ISS) P63144 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 P62482 (/IPI) P62483 (/IPI) P63143 (/IPI) P63144 (/IPI) P97382 (/IPI)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
4 P62483 (/IDA) P63144 (/IDA) Q13303 (/IDA) Q14722 (/IDA)
Aldo-keto reductase (NADP) activity GO:0004033
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
2 P62483 (/IDA) P63144 (/IDA)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
2 P62482 (/ISO) P63143 (/ISO)
Potassium channel regulator activity GO:0015459
Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification).
2 O43448 (/TAS) Q14722 (/TAS)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
2 P62483 (/IPI) P63144 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 Q14722 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P63143 (/ISO)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 Q14722 (/IDA)
NADPH binding GO:0070402
Interacting selectively and non-covalently with the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
1 P63143 (/ISO)

There are 30 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
9 P62482 (/ISS) P63143 (/ISS) Q13303 (/ISS) Q14722 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PTM5 (/ISS) Q9XT31 (/ISS)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
8 P62482 (/ISS) P63143 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PTM5 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
Regulation of delayed rectifier potassium channel activity GO:1902259
Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.
5 P63143 (/ISS) Q14722 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9XT31 (/ISS)
NADPH oxidation GO:0070995
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
4 P62482 (/ISS) Q13303 (/ISS) Q27955 (/ISS) Q9PTM5 (/ISS)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
3 P62483 (/IDA) Q13303 (/IDA) Q14722 (/IDA)
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
3 P62482 (/ISS) Q13303 (/ISS) Q27955 (/ISS)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 O43448 (/TAS) Q14722 (/TAS)
Myoblast differentiation GO:0045445
The process in which a relatively unspecialized cell acquires specialized features of a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers.
2 P62483 (/IEP) P63144 (/IEP)
Regulation of transmission of nerve impulse GO:0051969
Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.
2 E7F8K2 (/IMP) E9QGU5 (/IMP)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
2 P62483 (/IDA) P63144 (/IDA)
Regulation of action potential GO:0098900
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
2 E7F8K2 (/IMP) E9QGU5 (/IMP)
Regulation of potassium ion transmembrane transport GO:1901379
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transport.
2 P62482 (/ISO) P63143 (/ISO)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 P62482 (/IGI)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 P63144 (/IEP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 P63144 (/IEP)
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
1 P63144 (/IEP)
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
1 P63143 (/IMP)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
1 Q13303 (/TAS)
Neuromuscular process GO:0050905
Any process pertaining to the functions of the nervous and muscular systems of an organism.
1 P62482 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P62483 (/IPI)
Diaphragm development GO:0060539
The progression of the diaphragm over time from its initial formation to the mature structure. The diaphragm is a skeletal muscle that is responsible for contraction and expansion of the lungs.
1 P63144 (/IEP)
NADPH oxidation GO:0070995
A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADPH, to the oxidized form, NADP.
1 P62483 (/IDA)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
1 O59826 (/ISM)
Regulation of potassium ion transmembrane transporter activity GO:1901016
Any process that modulates the frequency, rate or extent of potassium ion transmembrane transporter activity.
1 P63143 (/IMP)
Regulation of delayed rectifier potassium channel activity GO:1902259
Any process that modulates the frequency, rate or extent of delayed rectifier potassium channel activity.
1 P63144 (/IDA)
Negative regulation of delayed rectifier potassium channel activity GO:1902260
Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.
1 P63144 (/IDA)
Negative regulation of delayed rectifier potassium channel activity GO:1902260
Any process that stops, prevents or reduces the frequency, rate or extent of delayed rectifier potassium channel activity.
1 P63144 (/IMP)
Negative regulation of voltage-gated potassium channel activity GO:1903817
Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity.
1 Q14722 (/IMP)
Negative regulation of voltage-gated potassium channel activity GO:1903817
Any process that stops, prevents or reduces the frequency, rate or extent of voltage-gated potassium channel activity.
1 P63143 (/ISO)
Regulation of protein localization to cell surface GO:2000008
Any process that modulates the frequency, rate or extent of protein localization to the cell surface.
1 P62483 (/IMP)

There are 37 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 P62482 (/ISS) P63143 (/ISS) P63144 (/ISS) Q13303 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PTM5 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
9 P62482 (/ISS) P63143 (/ISS) P63144 (/ISS) Q13303 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
Potassium channel complex GO:0034705
An ion channel complex through which potassium ions pass.
7 P62482 (/ISS) P63143 (/ISS) Q27955 (/ISS) Q28528 (/ISS) Q4PJK1 (/ISS) Q9PWR1 (/ISS) Q9XT31 (/ISS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
4 H0YWU3 (/IDA) P62482 (/IDA) P62483 (/IDA) P63144 (/IDA)
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
4 P62482 (/IDA) P62483 (/IDA) P63144 (/IDA) Q13303 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O59826 (/IDA) P62483 (/IDA) Q14722 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O43448 (/TAS) Q13303 (/TAS) Q14722 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 O23016 (/IDA) P63144 (/IDA) Q13303 (/IDA)
Potassium channel complex GO:0034705
An ion channel complex through which potassium ions pass.
3 P62483 (/IDA) P63144 (/IDA) Q14722 (/IDA)
Pinceau fiber GO:1990031
Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment.
3 P62482 (/ISS) Q13303 (/ISS) Q27955 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O23016 (/IDA) P63144 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
2 P63144 (/IDA) Q13303 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
2 P62482 (/ISO) P63143 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P62482 (/ISS) Q27955 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
2 P62483 (/IDA) Q14722 (/IDA)
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
2 Q13303 (/ISS) Q27955 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O59826 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P63143 (/ISO)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 P63143 (/IC)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
1 Q14722 (/IMP)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
1 O23016 (/IDA)
Postsynaptic density GO:0014069
An electron dense network of proteins within and adjacent to the postsynaptic membrane in asymetric synapses. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components.
1 P62482 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P62482 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q27955 (/ISS)
Extrinsic component of cytoplasmic side of plasma membrane GO:0031234
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.
1 P63143 (/ISO)
Dendrite cytoplasm GO:0032839
All of the contents of a dendrite, excluding the surrounding plasma membrane.
1 P63144 (/IDA)
Potassium channel complex GO:0034705
An ion channel complex through which potassium ions pass.
1 P63143 (/ISO)
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
1 Q13303 (/TAS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P62483 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q27955 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P63144 (/IDA)
Perikaryon GO:0043204
The portion of the cell soma (neuronal cell body) that excludes the nucleus.
1 P63144 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 P62482 (/IDA)
Juxtaparanode region of axon GO:0044224
A region of an axon near a node of Ranvier that is between the paranode and internode regions.
1 P62482 (/ISO)
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
1 Q13303 (/TAS)
Pinceau fiber GO:1990031
Dense plexus formed by the descending collaterals of cerebellar basket cells that wrap around a Purkinje cell axonal initial segment.
1 P62483 (/IDA)
Proximal dendrite GO:1990635
That part of the dendrite closest to the cell body of the neuron.
1 P63144 (/IDA)