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CATH Superfamily 3.20.20.100

NADP-dependent oxidoreductase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
NADP-dependent oxidoreductase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 15009: Oxidoreductase, aldo/keto reductase family

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pyridoxine 4-dehydrogenase. [EC: 1.1.1.65]
Pyridoxine + NADP(+) = pyridoxal + NADPH.
  • Also oxidizes pyridoxine phosphate.
 170 A0A075K835 A0A075K835 A0A078BFX6 A0A078BFX6 A0A098GDL8 A0A098GDL8 A0A0B8NH19 A0A0B8NH19 A0A0D5M1N0 A0A0D5M1N0
(160 more...)
D-threo-aldose 1-dehydrogenase. [EC: 1.1.1.122]
A D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + NADH.
  • Acts on L-fucose, D-arabinose and L-xylose.
  • The animal enzyme was also shown to act on L-arabinose, and the enzyme from Pseudomonas caryophylli on L-glucose.
 26 A0A0A0TV38 A0A0A0TV38 A0A0D6I307 A0A0D6I307 A0A0E2L8P6 A0A0E2L8P6 A0A0G3J8V1 A0A0G3J8V1 A0A0H2YW19 A0A0H2YW19
(16 more...)
20-alpha-hydroxysteroid dehydrogenase. [EC: 1.1.1.149]
17-alpha,20-alpha-dihydroxypregn-4-en-3-one + NAD(P)(+) = 17-alpha- hydroxyprogesterone + NAD(P)H.
  • Re-specific with respect to NAD(P)(+) (cf. EC 1.1.1.62).
 6 A0A083ZNP8 A0A083ZNP8 Q8U5N2 Q8U5N2 W6R6J3 W6R6J3
Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.2]
An alcohol + NADP(+) = an aldehyde + NADPH.
  • Some members of this group oxidize only primary alcohols; others act also on secondary alcohols.
  • May be identical with EC 1.1.1.19, EC 1.1.1.33 and EC 1.1.1.55.
  • Re-specific with respect to NADPH.
 6 K7SED0 K7SED0 K7SHK3 K7SHK3 K7SRP7 K7SRP7
Aryl-alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.91]
An aromatic alcohol + NADP(+) = an aromatic aldehyde + NADPH.
  • Also acts on some aliphatic aldehydes, but cinnamaldehyde was the best substrate found.
 4 D2T714 D2T714 D8J250 D8J250
Prostaglandin-F synthase. [EC: 1.1.1.188]
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH.
  • Reduces prostaglandin D(2) and prostaglandin H(2) to prostaglandin F(2); prostaglandin D(2) is not an intermediate in the reduction of prostaglandin H(2).
  • Also catalyzes the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone.
 4 A0A031GKE8 A0A031GKE8 G0AE82 G0AE82
Perakine reductase. [EC: 1.1.1.317]
Raucaffrinoline + NADP(+) = perakine + NADPH.
  • The biosynthesis of raucaffrinoline from perakine is a side route of the ajmaline biosynthesis pathway.
  • The enzyme is a member of the aldo-keto reductase enzyme superfamily from higher plants.
 2 Q3L181 Q3L181
Aryl-alcohol dehydrogenase. [EC: 1.1.1.90]
An aromatic alcohol + NAD(+) = an aromatic aldehyde + NADH.
  • A group of enzymes with broad specificity toward primary alcohols with an aromatic or cyclohex-1-ene ring, but with low or no activity toward short-chain aliphatic alcohols.
 2 D8J250 D8J250
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