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CATH Superfamily 3.20.190.10

MutM-like, N-terminal

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
MutM-like, N-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1672: DNA glycosylase

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA-formamidopyrimidine glycosylase. [EC: 3.2.2.23]
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.
  • May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents.
  • Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.
 16 A0A045K2B2 A0A083W471 A0A0G4E339 A0A0H3LBU2 A0A0H3MCP5 A0A109SPR1 A0A109SYM8 A0A197IXG8 A0A1K2TJS1 A5U5G0
(6 more...)
DNA-(apurinic or apyrimidinic site) lyase. [EC: 4.2.99.18]
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
  • 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis.
  • This group of enzymes was previously listed as endonucleases, under the number EC 3.1.25.2.
 15 A0A045K2B2 A0A083W471 A0A0G4E339 A0A0H3LBU2 A0A0H3MCP5 A0A109SPR1 A0A109SYM8 A0A197IXG8 A5U5G0 F8M240
(5 more...)
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