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CATH Superfamily 3.20.19.10

Aconitase, domain 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Aconitase, domain 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 4374: 3-isopropylmalate dehydratase small subunit

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-isopropylmalate dehydratase. [EC: 4.2.1.33]
(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate.
  • Forms part of the leucine-biosynthesis pathway.
  • Brings about the interconversion of the two isomers of isopropylmalate.
 2296 A0A010Z3F8 A0A011UHA3 A0A016QL88 A0A022GDC9 A0A031LRX0 A0A031W945 A0A034T828 A0A037Z7B7 A0A049E5D6 A0A058YK75
(2286 more...)
Homoaconitate hydratase. [EC: 4.2.1.36]
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4- tricarboxylate + H(2)O.
  • The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyze the reaction shown above but cannot catalyze the previously described reaction, i.e. formation of homocitrate by hydration of cis-homoaconitate.
  • The enzyme responsible for the conversion of cis-homoaconitate into homocitrate in T.thermophilus is unknown at present but the reaction can be catalyzed in vitro using EC 4.2.1.3 from pig.
 312 A0A015M5B2 A0A058YK75 A0A060TC05 A0A061AI12 A0A061H651 A0A061HJJ8 A0A063BP74 A0A066VCJ6 A0A066W4T0 A0A067MUD1
(302 more...)
Methanogen homoaconitase. [EC: 4.2.1.114]
(R)-2-hydroxybutane-1,2,4-tricarboxylate = (1R,2S)-1-hydroxybutane-1,2,4- tricarboxylate.
  • Catalyzes several reactions in the pathway of coenzyme-B biosynthesis in methanogenic archaea.
  • In contrast to EC 4.2.1.36, this enzyme can catalyze both the dehydration of (R)-homocitrate to form cis-homoaconitate and the subsequent hydration reaction that forms homoisocitrate.
  • In addition to cis-homoaconitate, the enzyme can also catalyze the hydration of the physiological substrates dihomocitrate and trihomocitrate as well as the non-physiological substrate tetrahomocitrate.
  • Cis-aconitate and threo-DL-isocitrate cannot act as substrates, and (S)-homocitrate and trans-homoaconitate act as inhibitors of the enzyme.
 110 A0A062UYY6 A0A076LIG2 A0A090I4V8 A0A099T0A4 A0A0E3HA47 A0A0E3KTD3 A0A0E3LBH7 A0A0E3NDF9 A0A0E3NPB7 A0A0E3NX69
(100 more...)
Dimethylmaleate hydratase. [EC: 4.2.1.85]
(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H(2)O.
  • Inhibited by oxygen.
  • Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri.
  • Other enzymes involved in this pathway are EC 1.17.5.1, EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6 and EC 4.1.3.32.
 34 A0A0D6HVK0 A0A0F0CHD6 A0A0J9CBJ0 A0A0J9CBJ4 A0A0N9Y345 A0A0P0MAP1 A0A0P0MCB5 A0A142XTN1 A0A174RAZ8 A0A174XED5
(24 more...)
(R)-2-methylmalate dehydratase. [EC: 4.2.1.35]
(R)-2-methylmalate = 2-methylmaleate + H(2)O.
    		 12 A0A075KDR2 A0A075MVL4 A0A0P0RML6 A0A162QFT0 A0A1M4M2T0 G2SGP4 H8I875 I7LMY9 M1ZC93 N0E4X2
    (2 more...)
    3-isopropylmalate dehydrogenase. [EC: 1.1.1.85]
    (2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.
      		 5 A0A015KQY3 A0A0L0T9B5 A0A137PBW5 Q8KER9 U9SNX6
      Maleate hydratase. [EC: 4.2.1.31]
      (R)-malate = maleate + H(2)O.
        		 3 M1ZC93 N0E4X2 Q58673
        Aconitate hydratase. [EC: 4.2.1.3]
        Citrate = isocitrate.
        • Besides interconverting citrate and cis-aconitate, it also interconverts cis-aconitate with isocitrate and, hence, interconverts citrate and isocitrate.
        • The equilibrium mixture is 91% citrate, 6% isocitrate and 3% aconitate.
        • Cis-aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3- tricarboxylate.
        • Formerly EC 4.2.1.4.
        		 2 A0A0W8E362 F6BJJ8
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