CATH Superfamily 3.10.450.50
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 23122: Nuclear transport factor 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
|
4 | P61971 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) Q86HW7 (/ISS) |
|
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
4 | P61971 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) Q86HW7 (/ISS) |
|
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
3 | P33331 (/IPI) P61970 (/IPI) P61972 (/IPI) |
|
Nucleocytoplasmic transporter activity GO:0005487
Enables the directed movement of substances between the nucleus and the cytoplasm of a cell.
|
2 | P61970 (/IDA) P61972 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P61970 (/IPI) P61972 (/IPI) |
|
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
2 | P61971 (/ISO) Q10100 (/ISO) |
|
Protein transmembrane transporter activity GO:0008320
Enables the transfer of a protein from one side of a membrane to the other.
|
1 | P61971 (/ISO) |
|
Ran GTPase binding GO:0008536
Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly.
|
1 | P61970 (/IDA) |
|
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
|
1 | P61971 (/IDA) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
4 | Q32KP9 (/ISS) Q5R8G4 (/ISS) Q86HW7 (/ISS) Q8ILX1 (/ISS) |
|
Protein localization to nuclear pore GO:0090204
A process in which a protein is transported to, or maintained in, a nuclear pore.
|
4 | P61970 (/ISS) P61971 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) |
|
Positive regulation of antimicrobial peptide biosynthetic process GO:0002807
Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis.
|
3 | A8JUT4 (/IMP) D0Z726 (/IMP) Q9VRD6 (/IMP) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
3 | P33331 (/IMP) P61972 (/IMP) Q9FZK4 (/IMP) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | P61970 (/IDA) P61971 (/IDA) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
2 | P61971 (/ISO) Q10100 (/ISO) |
|
Protein import into nucleus, translocation GO:0000060
A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
|
1 | P61970 (/IMP) |
|
Protein import into nucleus, translocation GO:0000060
A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
|
1 | P61971 (/ISO) |
|
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
1 | P61970 (/IDA) |
|
Protein export from nucleus GO:0006611
The directed movement of a protein from the nucleus into the cytoplasm.
|
1 | P61971 (/ISO) |
|
Nucleocytoplasmic transport GO:0006913
The directed movement of molecules between the nucleus and the cytoplasm.
|
1 | P33331 (/IMP) |
|
Positive regulation of protein import into nucleus GO:0042307
Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus.
|
1 | P61972 (/IMP) |
|
Response to mercury ion GO:0046689
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mercury ion stimulus.
|
1 | Q86HW7 (/RCA) |
|
Protein localization to nuclear pore GO:0090204
A process in which a protein is transported to, or maintained in, a nuclear pore.
|
1 | P61972 (/IMP) |
|
Negative regulation of vascular endothelial growth factor production GO:1904046
Any process that stops, prevents or reduces the frequency, rate or extent of vascular endothelial growth factor production.
|
1 | P61972 (/IMP) |
There are 18 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
5 | P61971 (/ISS) P61972 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) Q86HW7 (/ISS) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
4 | A8MS55 (/IDA) P33331 (/IDA) Q10100 (/IDA) Q9FZK4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A8MS55 (/IDA) P61970 (/IDA) P61972 (/IDA) Q10100 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P61971 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) Q86HW7 (/ISS) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
4 | P61970 (/ISS) P61971 (/ISS) Q32KP9 (/ISS) Q5R8G4 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q10100 (/IDA) Q9FZK4 (/IDA) |
|
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
|
1 | Q86HW7 (/ISS) |
|
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
|
1 | P61972 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P61970 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | P61971 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9FZK4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P61971 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | A8MS55 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | P61972 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
1 | Q10100 (/ISO) |
|
Nuclear pore central transport channel GO:0044613
The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153.
|
1 | P61972 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P61970 (/IDA) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P61971 (/ISO) |
