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CATH Superfamily 3.10.450.50

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 23083: Biphenyl dioxygenase subunit beta

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-phenylpropanoate dioxygenase. [EC: 1.14.12.19]
(1) 3-phenylpropanoate + NADH + O(2) = 3-(cis-5,6-dihydroxycyclohexa-1,3- dien-1-yl)propanoate + NAD(+). (2) (2E)-3-phenylprop-2-enoate + NADH + O(2) = (2E)-3-(2,3- dihydroxyphenyl)prop-2-enoate + NAD(+).
  • This enzyme catalyzes a step in the pathway of phenylpropanoid compounds degradation.
  • It catalyzes the insertion of both atoms of molecular oxygen into positions 2 and 3 of the phenyl ring of 3-phenylpropanoate or (2E)-3- phenylprop-2-enoate.
 500 A0A009FNX0 A0A009FNX0 A0A022PRZ4 A0A022PRZ4 A0A023Z125 A0A023Z125 A0A024KYG7 A0A024KYG7 A0A025CD94 A0A025CD94
(490 more...)
Benzene 1,2-dioxygenase. [EC: 1.14.12.3]
Benzene + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+).
  • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase and ferredoxin.
 40 A0A009FNX0 A0A009FNX0 A0A0A3W933 A0A0A3W933 A0A0A8J3G2 A0A0A8J3G2 A1VUW0 A1VUW0 A5W4F1 A5W4F1
(30 more...)
Biphenyl 2,3-dioxygenase. [EC: 1.14.12.18]
Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
  • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
  • Chlorine-substituted biphenyls can also act as substrates.
  • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
 32 A0A062BWQ5 A0A062BWQ5 A0A0E2H3M2 A0A0E2H3M2 A0A0P0UW08 A0A0P0UW08 A0A1D3K930 A0A1D3K930 A0A1L7FXE5 A0A1L7FXE5
(22 more...)
Toluene dioxygenase. [EC: 1.14.12.11]
Toluene + NADH + O(2) = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+).
  • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), an iron-sulfur oxygenase, and a ferredoxin.
  • Some other aromatic compounds, including ethylbenzene, 4-xylene and some halogenated toluenes, are converted into the corresponding cis- dihydrodiols.
 10 A5W4F1 A5W4F1 I7CA88 I7CA88 P0C619 P0C619 Q49KD7 Q49KD7 V9UZJ4 V9UZJ4
Benzoate 1,2-dioxygenase. [EC: 1.14.12.10]
Benzoate + NADH + O(2) = (1R,6S)-1,6-dihydroxycyclohexa-2,4-diene-1- carboxylate + NAD(+).
  • A system, containing a reductase which is an iron-sulfur flavoprotein (FAD), and an iron-sulfur oxygenase.
  • Formerly EC 1.13.99.2.
 4 A0A156KAW7 A0A156KAW7 A0A1C0PFE6 A0A1C0PFE6