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CATH Superfamily 3.10.180.10

2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2903: Extradiol ring-cleavage dioxygenase family protein

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3,4-dihydroxyphenylacetate 2,3-dioxygenase. [EC: 1.13.11.15]
3,4-dihydroxyphenylacetate + O(2) = 2-hydroxy-5-carboxymethylmuconate semialdehyde.
    		 3 B6B4G6 B7QVK1 C9CSZ8
    Biphenyl-2,3-diol 1,2-dioxygenase. [EC: 1.13.11.39]
    Biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate.
    • This enzyme participates in the degradation pathway of biphenyl and PCB (poly chlorinated biphenyls), and catalyzes the first ring cleavage step by incorporating two oxygen atoms into the catechol ring formed by EC 1.3.1.56.
    • The enzyme from the bacterium Burkholderia xenovorans LB400 can also process catechol, 3-methylcatechol, and 4-methylcatechol, but less efficiently.
    • The enzyme from the carbazole-degrader Pseudomonas resinovorans strain CA10 also accepts 2'-aminobiphenyl-2,3-diol.
    • The enzyme from Ralstonia sp. SBUG 290 can also accept 1,2- dihydroxydibenzofuran and 1,2-dihydroxynaphthalene.
    • The enzyme is strongly inhibited by the substrate.
    • Not identical with EC 1.13.11.2.
    		 2 A0A0H5D4W1 A0A0P1H7L3