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CATH Superfamily 3.10.180.10

2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25382: Probable 4-hydroxyphenylpyruvate dioxygenase 1

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
4-hydroxyphenylpyruvate dioxygenase. [EC: 1.13.11.27]
4-hydroxyphenylpyruvate + O(2) = homogentisate + CO(2).
  • Formerly EC 1.14.2.2 and EC 1.99.1.14.
 2678 A0A009GAQ5 A0A009GAQ5 A0A009HEX7 A0A009HEX7 A0A009HIJ6 A0A009HIJ6 A0A009IRX1 A0A009IRX1 A0A009JX13 A0A009JX13
(2668 more...)
4-hydroxymandelate synthase. [EC: 1.13.11.46]
4-hydroxyphenylpyruvate + O(2) = (S)-4-hydroxymandelate + CO(2).
  • Involved in the biosynthesis of the vancomycin group of glycopeptide antibiotics.
 24 A0A062WQG3 A0A062WQG3 A0A075UYC1 A0A075UYC1 A0A0K2B0T1 A0A0K2B0T1 A0A0N0VKG3 A0A0N0VKG3 A0A1B9EJB1 A0A1B9EJB1
(14 more...)
Lactoylglutathione lyase. [EC: 4.4.1.5]
(R)-S-lactoylglutathione = glutathione + methylglyoxal.
  • Also acts on 3-phosphoglycerol-glutathione.
 4 A0A161MTI1 A0A161MTI1 T1B7G8 T1B7G8
Catechol 2,3-dioxygenase. [EC: 1.13.11.2]
Catechol + O(2) = 2-hydroxymuconate-6-semialdehyde.
  • The enzyme initiates the meta-cleavage pathway of catechol degradation.
  • Formerly EC 1.13.1.2.
 2 A0A0P1BXB9 A0A0P1BXB9
Glutathione-disulfide reductase. [EC: 1.8.1.7]
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
  • Activity is dependent on a redox-active disulfide in each of the active centers.
  • Formerly EC 1.6.4.2.
 2 G8QAJ3 G8QAJ3
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