The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25377: Glyoxalase domain-containing protein 4

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Lactoylglutathione lyase. [EC: 4.4.1.5]
(R)-S-lactoylglutathione = glutathione + methylglyoxal.
  • Also acts on 3-phosphoglycerol-glutathione.
10 B7QBY6 B7QBY6 C1L7I9 C1L7I9 C1L7J4 C1L7J4 G4VDP7 G4VDP7 Q86F38 Q86F38
Protein-S-isoprenylcysteine O-methyltransferase. [EC: 2.1.1.100]
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
  • C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, more slowly.
  • Formerly EC 2.1.1.24.
6 A0A068XF43 A0A068XF43 A0A0R3W448 A0A0R3W448 A0A0R3X165 A0A0R3X165
3-hydroxyisobutyrate dehydrogenase. [EC: 1.1.1.31]
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH.
    2 A0A0D8Y8E0 A0A0D8Y8E0
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