The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Ubiquitin Conjugating Enzyme
".
FunFam 6093: E3 ubiquitin-protein ligase RNF25
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | A0A0B4KHX7 (/NAS) Q9V9X8 (/NAS) |
|
Elongation factor-2 kinase activity GO:0004686
Catalysis of the reaction: ATP +
|
2 | A0A0B4KHX7 (/IDA) Q9V9X8 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | Q5E9N3 (/ISS) Q96BH1 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P15442 (/IPI) Q9QZR0 (/IPI) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
2 | Q5E9N3 (/ISS) Q9QZR0 (/ISS) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P15442 (/IDA) |
|
TRNA binding GO:0000049
Interacting selectively and non-covalently with transfer RNA.
|
1 | P15442 (/IMP) |
|
Double-stranded RNA binding GO:0003725
Interacting selectively and non-covalently with double-stranded RNA.
|
1 | P15442 (/IDA) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | P15442 (/IDA) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | P15442 (/IDA) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | Q9HGN1 (/IMP) |
|
Eukaryotic translation initiation factor 2alpha kinase activity GO:0004694
Catalysis of the reaction: ATP +
|
1 | Q4WU06 (/ISA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q9QZR0 (/IDA) |
|
Translation initiation factor binding GO:0031369
Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.
|
1 | P15442 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P15442 (/IDA) |
|
Ribosome binding GO:0043022
Interacting selectively and non-covalently with any part of a ribosome.
|
1 | P15442 (/IDA) |
|
Ribosomal large subunit binding GO:0043023
Interacting selectively and non-covalently with any part of the larger ribosomal subunit.
|
1 | P15442 (/IDA) |
|
Protein self-association GO:0043621
Interacting selectively and non-covalently with a domain within the same polypeptide.
|
1 | P15442 (/IDA) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q96BH1 (/IPI) |
|
NF-kappaB binding GO:0051059
Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters.
|
1 | Q9QZR0 (/ISO) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q9QZR0 (/IDA) |
There are 39 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | A0A0B4KHX7 (/IDA) P15442 (/IDA) Q9V9X8 (/IDA) |
|
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
|
2 | A0A0B4KHX7 (/IC) Q9V9X8 (/IC) |
|
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
|
2 | A0A0B4KHX7 (/IC) Q9V9X8 (/IC) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | A0A0B4KHX7 (/NAS) Q9V9X8 (/NAS) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
2 | Q5E9N3 (/ISS) Q96BH1 (/ISS) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
2 | P15442 (/IMP) Q4WU06 (/IMP) |
|
Positive regulation of cell size GO:0045793
Any process that increases cell size.
|
2 | A0A0B4KHX7 (/IGI) Q9V9X8 (/IGI) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
2 | Q5E9N3 (/ISS) Q9QZR0 (/ISS) |
|
DNA damage checkpoint GO:0000077
A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
|
1 | P15442 (/IMP) |
|
Chronological cell aging GO:0001300
The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state.
|
1 | P15442 (/IMP) |
|
Cytoplasmic translational initiation GO:0002183
The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA.
|
1 | Q9HGN1 (/NAS) |
|
Regulation of translational initiation GO:0006446
Any process that modulates the frequency, rate or extent of translational initiation.
|
1 | P15442 (/IDA) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P15442 (/IMP) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q9QZR0 (/IDA) |
|
Mitotic G1 DNA damage checkpoint GO:0031571
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage.
|
1 | Q9HGN1 (/IMP) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | P15442 (/IDA) |
|
Cellular response to amino acid starvation GO:0034198
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids.
|
1 | Q9HGN1 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | P15442 (/IDA) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | P15442 (/IMP) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | Q96BH1 (/IDA) |
|
Positive regulation of NF-kappaB transcription factor activity GO:0051092
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
|
1 | Q9QZR0 (/ISO) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
1 | P15442 (/IDA) |
|
Regulation of eIF2 alpha phosphorylation by amino acid starvation GO:0060733
Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.
|
1 | P15442 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | P15442 (/IMP) |
|
Cellular response to hydrogen peroxide GO:0070301
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus.
|
1 | Q9HGN1 (/ISS) |
|
Cellular response to histidine GO:0071232
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histidine stimulus.
|
1 | P15442 (/IDA) |
|
Negative regulation of translational initiation in response to starvation GO:0071263
Any process that stops, prevents or reduces the rate of translation initiation, as a result of deprivation of nourishment.
|
1 | Q9HGN1 (/TAS) |
|
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
|
1 | P15442 (/IDA) |
|
Positive regulation of translational initiation in response to starvation GO:0071264
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.
|
1 | P15442 (/IMP) |
|
G1 cell cycle arrest in response to nitrogen starvation GO:0071849
The process in which the cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.
|
1 | Q9HGN1 (/IMP) |
|
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
|
1 | P15442 (/IMP) |
|
Cellular response to benomyl GO:0072755
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benomyl stimulus.
|
1 | Q9HGN1 (/ISS) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
1 | P15442 (/IDA) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
1 | P15442 (/IGI) |
|
Positive regulation of cellular response to amino acid starvation GO:1903833
Any process that activates or increases the frequency, rate or extent of cellular response to amino acid starvation.
|
1 | P15442 (/IMP) |
|
Regulation of translation involved in cellular response to UV GO:1904803
Any regulation of translation that is involved in cellular response to UV.
|
1 | Q9HGN1 (/IMP) |
|
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
|
1 | P15442 (/IMP) |
|
Cellular stress response to acidic pH GO:1990451
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution.
|
1 | Q9HGN1 (/ISS) |
|
Regulation of cytoplasmic translation in response to stress GO:1990497
Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
1 | Q9HGN1 (/IGI) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q5E9N3 (/ISS) Q9QZR0 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | A0A0B4KHX7 (/IC) Q9V9X8 (/IC) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q5E9N3 (/ISS) Q9QZR0 (/ISS) |
|
Precatalytic spliceosome GO:0071011
A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs.
|
2 | A0A0B4KHX7 (/IDA) Q9V9X8 (/IDA) |
|
Catalytic step 2 spliceosome GO:0071013
A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs.
|
2 | A0A0B4KHX7 (/IDA) Q9V9X8 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q96BH1 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9QZR0 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q96BH1 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9QZR0 (/ISO) |
|
Large ribosomal subunit GO:0015934
The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site).
|
1 | P15442 (/IDA) |
|
Small ribosomal subunit GO:0015935
The smaller of the two subunits of a ribosome.
|
1 | P15442 (/IDA) |
|
Cytosolic ribosome GO:0022626
A ribosome located in the cytosol.
|
1 | P15442 (/IDA) |
|
Polysomal ribosome GO:0042788
A ribosome bound to mRNA that forms part of a polysome.
|
1 | P15442 (/IDA) |
