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CATH Superfamily 3.10.110.10

Ubiquitin Conjugating Enzyme

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Ubiquitin Conjugating Enzyme
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6050: Ubiquitin-conjugating enzyme E2 2

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
E2 ubiquitin-conjugating enzyme. [EC: 2.3.2.23]
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine.
  • The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself.
  • In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
  • Formerly EC 6.3.2.19.
 219 A0A034VNX7 A0A060Y5E2 A0A078F4C8 A0A078IX24 A0A086TEP6 A0A087GUA9 A0A087HNI3 A0A090N5A3 A0A091CNX5 A0A091F292
(209 more...)
Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45. [EC: 6.3.2.19]
    		174 A0A060SVX7 A0A060TCN2 A0A061FY21 A0A067G8T1 A0A067KG63 A0A074SWD6 A0A074TLU9 A0A075ARC8 A0A077TPF1 A0A078K9I3
    (164 more...)
    (E3-independent) E2 ubiquitin-conjugating enzyme. [EC: 2.3.2.24]
    S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)- monoubiquitinyl-[acceptor protein]-L-lysine.
    • The enzyme transfers a single ubiquitin directly from an ubiquitinated E1 ubiquitin-activating enzyme to itself, and on to a lysine residue of the acceptor protein without involvement of E3 ubiquitin transferases (cf. EC 2.3.2.26, EC 2.3.2.27).
    • It forms a labile ubiquitin adduct in the presence of E1, ubiquitin, and Mg(2+)-ATP and catalyzes the conjugation of ubiquitin to protein substrates, independently of E3.
    • This transfer has only been observed with small proteins.
    • In vitro a transfer to small acceptors (e.g. L-lysine, N-acetyl-L- lysine methyl ester) has been observed.
    		 14 A0A0D9SB30 A0A1L8ETU3 A2A4Z0 F7HGB1 H2P240 H2QKH0 O00762 P56616 Q32PA5 Q4R9D1
    (4 more...)
    Pectate lyase. [EC: 4.2.2.2]
    Eliminative cleavage of (1->4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.
    • Favors pectate, the anion, over pectin, the methyl ester (which is the preferred substrate of EC 4.2.2.10).
    • Formerly EC 4.2.99.3.
    		 1 A0A0D3DXD1