The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Mannose-Binding Protein A, subunit A
".
FunFam 12450: Natural killer cell receptor-P1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | D3W0D1 (/IPI) Q0ZUP1 (/IPI) Q12918 (/IPI) Q8VD98 (/IPI) Q9R007 (/IPI) |
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
|
2 | Q9NY25 (/IDA) Q9R007 (/IDA) |
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
|
2 | Q0ZUP1 (/IDA) Q8VD98 (/IDA) |
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
2 | Q12918 (/TAS) Q9NZS2 (/TAS) |
Virus receptor activity GO:0001618
Combining with a virus component and mediating entry of the virus into the cell.
|
1 | Q9R007 (/ISO) |
Carbohydrate binding GO:0030246
Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
|
1 | Q12918 (/TAS) |
MHC class I receptor activity GO:0032393
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
|
1 | Q9NZS2 (/TAS) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | D3W0D1 (/IDA) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
|
2 | Q9GLF3 (/ISS) Q9NY25 (/ISS) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
2 | Q12918 (/TAS) Q9NZS2 (/TAS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | Q9GLF3 (/ISS) Q9NY25 (/ISS) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
2 | Q9NY25 (/IDA) Q9R007 (/IDA) |
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
2 | Q12918 (/TAS) Q9NZS2 (/TAS) |
Osteoblast development GO:0002076
The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.
|
1 | Q9R007 (/IDA) |
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
1 | Q9NY25 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q9NY25 (/TAS) |
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
1 | Q9R007 (/IGI) |
Negative regulation of myeloid cell apoptotic process GO:0033033
Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.
|
1 | Q9R007 (/IDA) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q9R007 (/IDA) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | Q9NY25 (/TAS) |
Natural killer cell degranulation GO:0043320
The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell.
|
1 | D3W0D1 (/TAS) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q9R007 (/ISO) |
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q9NY25 (/TAS) |
Cytokine secretion GO:0050663
The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
|
1 | D3W0D1 (/TAS) |
Positive regulation of cytokine secretion GO:0050715
Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.
|
1 | Q9R007 (/IMP) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q12918 (/TAS) Q9NY25 (/TAS) Q9NZS2 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | Q9NY25 (/TAS) Q9NZS2 (/TAS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q8VD98 (/IDA) Q9R007 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | Q9GLF3 (/ISS) Q9NY25 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8VD98 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | D3W0D1 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9NZS2 (/TAS) |
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | Q9NY25 (/TAS) |
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
|
1 | Q9NY25 (/TAS) |