The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"HIV Type 1 Reverse Transcriptase, subunit A, domain 1
".
FunFam 831: Pol polyprotein
There are 4 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
RNA-directed DNA polymerase.
[EC: 2.7.7.49]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
10 | P10266 P63128 P63132 P63133 P63135 P63136 Q9BXR3 Q9QC07 Q9UQG0 Q9WJR5 |
Ribonuclease H.
[EC: 3.1.26.4]
Endonucleolytic cleavage to 5'-phosphomonoester.
|
10 | P10266 P63128 P63132 P63133 P63135 P63136 Q9BXR3 Q9QC07 Q9UQG0 Q9WJR5 |
Human endogenous retrovirus K endopeptidase.
[EC: 3.4.23.50]
Processing at the authentic HIV-1 PR recognition site and release of the mature p17 matrix and the p24 capsid protein, as a result of the cleavage of the -SQNY-|-PIVQ- cleavage site.
|
1 | P63128 |
DNA-directed DNA polymerase.
[EC: 2.7.7.7]
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | P63128 |