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CATH Superfamily 2.70.98.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 7234: Putative xanthan lyase XalB

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hyaluronate lyase. [EC: 4.2.2.1]
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
  • The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction.
  • Also acts on chondroitin.
  • The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose.
  • Formerly EC 4.2.99.1.
 235 A0A077UG77 A0A077UIU7 A0A098ZCV0 A0A0C6FJF2 A0A0D6H7X3 A0A0E0VRU5 A0A0E0VT36 A0A0E1AJ65 A0A0E1VGH8 A0A0E1X476
(225 more...)
Chondroitin AC lyase. [EC: 4.2.2.5]
Eliminative degradation of polysaccharides containing 1,4-beta-D- hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups.
  • Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate.
  • In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region.
  • The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta-1- 3)GalNAc(beta-1-](n), which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA.
  • GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha-1-3)GalNAc(beta-1-](n) of DS.
  • Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source.
  • Formerly EC 4.2.99.6.
 1 Q59288
Xanthan lyase. [EC: 4.2.2.12]
Eliminative cleavage of the terminal beta-D-mannosyl-(1->4)-beta-D- glucuronosyl linkage of the side-chain of the polysaccharide xanthan, leaving a 4-deoxy-alpha-L-threo-hex-4-enuronosyl group at the terminus of the side-chain.
    		 1 Q9AQS0
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