The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 663: RE56180p

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein transporter activity GO:0008565
Enables the directed movement of proteins into, out of or within a cell, or between cells.
4 Q7KVR7 (/IC) Q7KVR8 (/IC) Q86B59 (/IC) Q9W388 (/IC)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q8WQB3 (/IPI)
Clathrin binding GO:0030276
Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles.
1 Q8WQB3 (/ISS)

There are 8 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vesicle coating GO:0006901
A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.
4 Q7KVR7 (/TAS) Q7KVR8 (/TAS) Q86B59 (/TAS) Q9W388 (/TAS)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
4 Q7KVR7 (/NAS) Q7KVR8 (/NAS) Q86B59 (/NAS) Q9W388 (/NAS)
Synaptic vesicle coating GO:0016183
The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles.
4 Q7KVR7 (/TAS) Q7KVR8 (/TAS) Q86B59 (/TAS) Q9W388 (/TAS)
Secretory granule organization GO:0033363
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a secretory granule. A secretory granule is a small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion.
4 Q7KVR7 (/IMP) Q7KVR8 (/IMP) Q86B59 (/IMP) Q9W388 (/IMP)
Cargo loading into clathrin-coated vesicle GO:0035652
Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle.
4 Q7KVR7 (/IMP) Q7KVR8 (/IMP) Q86B59 (/IMP) Q9W388 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
4 Q7KVR7 (/IMP) Q7KVR8 (/IMP) Q86B59 (/IMP) Q9W388 (/IMP)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
1 Q8WQB3 (/IMP)
Apical protein localization GO:0045176
Any process in which a protein is transported to, or maintained in, apical regions of the cell.
1 Q8WQB3 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Trans-Golgi network GO:0005802
The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
4 Q7KVR7 (/IDA) Q7KVR8 (/IDA) Q86B59 (/IDA) Q9W388 (/IDA)
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
4 Q7KVR7 (/TAS) Q7KVR8 (/TAS) Q86B59 (/TAS) Q9W388 (/TAS)
AP-1 adaptor complex GO:0030121
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
4 Q7KVR7 (/IMP) Q7KVR8 (/IMP) Q86B59 (/IMP) Q9W388 (/IMP)
AP-1 adaptor complex GO:0030121
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
4 Q7KVR7 (/IPI) Q7KVR8 (/IPI) Q86B59 (/IPI) Q9W388 (/IPI)
Coated vesicle GO:0030135
Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
4 Q7KVR7 (/TAS) Q7KVR8 (/TAS) Q86B59 (/TAS) Q9W388 (/TAS)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
4 Q7KVR7 (/IDA) Q7KVR8 (/IDA) Q86B59 (/IDA) Q9W388 (/IDA)
Secretory granule GO:0030141
A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules.
4 Q7KVR7 (/IDA) Q7KVR8 (/IDA) Q86B59 (/IDA) Q9W388 (/IDA)
Recycling endosome GO:0055037
An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane.
4 Q7KVR7 (/IDA) Q7KVR8 (/IDA) Q86B59 (/IDA) Q9W388 (/IDA)
AP-1 adaptor complex GO:0030121
A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).
1 Q8WQB3 (/ISS)
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