The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group.

The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.

Any process that modulates the frequency, rate or extent of macroautophagy.

The signaling process in which signal transduction is brought to an end rather than being reversibly modulated.

Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.

Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.

A process that modulates the rate or extent of water loss from an organism via the skin.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a testosterone stimulus.

Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.

Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components.

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics.

The chemical reactions and pathways resulting in the formation of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.

The chemical reactions and pathways resulting in the formation of ceramides, any N-acylated sphingoid.

Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.

Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein.

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.

A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.

Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.

The chemical reactions and pathways resulting in the breakdown of beta-glucoside.

Any process that activates or increases the frequency, rate or extent of proteolysis involved in cellular protein catabolic process.

Any process that activates or increases the frequency, rate or extent of protein lipidation.

Any process that activates or increases the frequency, rate or extent of neuronal action potential.

Any process that modulates the frequency, rate or extent of lysosomal protein catabolic process.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.

The volume enclosed within the lysosomal membrane.

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.