The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24209: Receptor-type tyrosine-protein phosphatase mu

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane receptor protein tyrosine phosphatase activity GO:0005001
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 P28827 (/IDA)
Protein tyrosine phosphatase activity GO:0004725
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 P28828 (/ISO)
Transmembrane receptor protein tyrosine phosphatase activity GO:0005001
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 P28827 (/IDA)
Transmembrane receptor protein tyrosine phosphatase activity GO:0005001
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
1 P28828 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P28827 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P28827 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 P28828 (/ISO)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P28827 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 P28828 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Retina layer formation GO:0010842
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
1 P28827 (/IMP)
Negative regulation of endothelial cell proliferation GO:0001937
Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.
1 P28828 (/ISO)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P28827 (/IDA)
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
1 P28828 (/ISO)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 P28827 (/IDA)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 P28828 (/ISO)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P28827 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P28828 (/ISO)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P28827 (/IMP)
Negative regulation of endothelial cell migration GO:0010596
Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P28828 (/ISO)
Retina layer formation GO:0010842
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
1 P28827 (/IMP)
Retina layer formation GO:0010842
The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.
1 P28828 (/ISO)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P28827 (/IMP)
Negative regulation of angiogenesis GO:0016525
Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
1 P28828 (/ISO)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P28827 (/IDA)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P28827 (/IMP)
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P28828 (/ISO)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 P28827 (/IDA)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
1 P28828 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P28827 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P28828 (/ISO)
Positive regulation of blood vessel diameter GO:0097755
Any process that increases the diameter of blood vessels.
1 P28828 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
15 A0A0G2K8V0 (/ISS) E1BPU9 (/ISS) F1LPJ1 (/ISS) F1PUP2 (/ISS) F6XDJ0 (/ISS) F6ZQ35 (/ISS) F7CJS5 (/ISS) G1LLN7 (/ISS) G1R5I4 (/ISS) G1TB02 (/ISS)
(5 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 E7EPS8 (/IDA) P28827 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P28827 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P28828 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P28828 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P28827 (/NAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P28827 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 P28828 (/ISO)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 P28827 (/IDA)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
1 P28828 (/ISO)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 P28827 (/IDA)
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
1 P28828 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P28827 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 P28828 (/ISO)