The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 137120: Tripartite motif-containing protein 45
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 14 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
11 |
A4IF63 (/ISS)
D2GXS7 (/ISS)
D3ZQG6 (/ISS)
D3ZVM4 (/ISS)
E1BJS7 (/ISS)
E7FAM5 (/ISS)
F6QEU4 (/ISS)
F7H9X2 (/ISS)
Q1PRL4 (/ISS)
Q2Q1W2 (/ISS)
(1 more) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | D3ZQG6 (/IPI) O70277 (/IPI) O75382 (/IPI) P13466 (/IPI) P13466 (/IPI) Q1PSW8 (/IPI) Q9C040 (/IPI) Q9ESN6 (/IPI) Q9R1R2 (/IPI) |
|
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
4 | E7F1U3 (/IDA) Q1PSW8 (/IDA) Q9ESN6 (/IDA) Q9R1R2 (/IDA) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
3 | Q1PSW8 (/IDA) Q9ESN6 (/IDA) Q9R1R2 (/IDA) |
|
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
2 | Q9C040 (/NAS) Q9ESN6 (/NAS) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | P13466 (/TAS) P13466 (/TAS) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
|
2 | P13466 (/TAS) P13466 (/TAS) |
|
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | O75382 (/TAS) |
|
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
|
1 | Q9ESN6 (/NAS) |
|
Translation repressor activity GO:0030371
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
|
1 | Q2Q1W2 (/IDA) |
|
Translation repressor activity GO:0030371
Antagonizes ribosome-mediated translation of mRNA into a polypeptide.
|
1 | Q1PSW8 (/ISO) |
|
MiRNA binding GO:0035198
Interacting selectively and non-covalently with a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes.
|
1 | Q1PSW8 (/IDA) |
There are 48 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Stem cell proliferation GO:0072089
The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Regulation of neural precursor cell proliferation GO:2000177
Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
|
5 | A4IF63 (/ISS) D2GXS7 (/ISS) D3ZQG6 (/ISS) F7H9X2 (/ISS) Q9C040 (/ISS) |
|
Myeloid cell differentiation GO:0030099
The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages.
|
3 | A0A0R4IF03 (/IMP) F1QFW2 (/IMP) Q58ER5 (/IMP) |
|
Primitive hemopoiesis GO:0060215
A first transient wave of blood cell production that, in vertebrates, gives rise to erythrocytes (red blood cells) and myeloid cells.
|
3 | A0A0R4IF03 (/IMP) F1QFW2 (/IMP) Q58ER5 (/IMP) |
|
Phagocytosis GO:0006909
An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
|
2 | P13466 (/IGI) P13466 (/IGI) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | P13466 (/IEP) P13466 (/IEP) |
|
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
|
2 | P13466 (/IGI) P13466 (/IGI) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
2 | P13466 (/IMP) P13466 (/IMP) |
|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | P13466 (/IMP) P13466 (/IMP) |
|
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
|
2 | P13466 (/IGI) P13466 (/IGI) |
|
Sorocarp development GO:0030587
The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum.
|
2 | P13466 (/IMP) P13466 (/IMP) |
|
Phototaxis GO:0042331
The directed movement of a motile cell or organism in response to light.
|
2 | P13466 (/IMP) P13466 (/IMP) |
|
Thermotaxis GO:0043052
The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature.
|
2 | P13466 (/IMP) P13466 (/IMP) |
|
Regulation of neuron apoptotic process GO:0043523
Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons.
|
2 | D3ZQG6 (/IMP) Q9ESN6 (/IMP) |
|
Cell motility GO:0048870
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another.
|
2 | P13466 (/IGI) P13466 (/IGI) |
|
Response to cAMP GO:0051591
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
G1/S transition of mitotic cell cycle GO:0000082
The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
|
1 | Q1PSW8 (/IMP) |
|
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q1PSW8 (/IMP) |
|
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
1 | O75382 (/TAS) |
|
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
|
1 | Q1PSW8 (/IMP) |
|
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
|
1 | E7FAM5 (/IMP) |
|
MiRNA metabolic process GO:0010586
The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression.
|
1 | Q1PSW8 (/IDA) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | Q9R1R2 (/IDA) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
|
1 | Q2Q1W2 (/IDA) |
|
Negative regulation of translation GO:0017148
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA.
|
1 | Q1PSW8 (/ISO) |
|
Neural tube development GO:0021915
The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium.
|
1 | Q1PSW8 (/IDA) |
|
MiRNA mediated inhibition of translation GO:0035278
The process in which microRNAs (miRNAs) block the translation of target mRNAs into proteins. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA will typically mediate repression of translation if the miRNA imperfectly base-pairs with the 3' untranslated regions of target mRNAs
|
1 | Q1PSW8 (/IMP) |
|
Regulation of protein metabolic process GO:0051246
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.
|
1 | Q1PSW8 (/IDA) |
|
Protein autoubiquitination GO:0051865
The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
|
1 | Q1PSW8 (/IDA) |
|
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
|
1 | Q6PFY8 (/IMP) |
|
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.
|
1 | Q1PSW8 (/IGI) |
|
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: mRNA cleavage or translational repression.
|
1 | Q1PSW8 (/IMP) |
|
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
|
1 | Q2Q1W2 (/IDA) |
|
3'-UTR-mediated mRNA destabilization GO:0061158
An mRNA destabilization process in which one or more RNA-binding proteins associate with the 3'-untranslated region (UTR) of an mRNA.
|
1 | Q1PSW8 (/ISO) |
|
Cellular response to organic substance GO:0071310
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | Q1PSW8 (/IDA) |
|
Stem cell proliferation GO:0072089
The multiplication or reproduction of stem cells, resulting in the expansion of a stem cell population. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
|
1 | Q1PSW8 (/IMP) |
|
Regulation of neural precursor cell proliferation GO:2000177
Any process that modulates the frequency, rate or extent of neural precursor cell proliferation.
|
1 | Q1PSW8 (/IMP) |
|
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
1 | Q1PSW8 (/IDA) |
|
Positive regulation of gene silencing by miRNA GO:2000637
Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA.
|
1 | Q1PSW8 (/IMP) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
6 | D3ZVM4 (/ISS) E1BJS7 (/ISS) E7FAM5 (/ISS) F6QEU4 (/ISS) Q1PRL4 (/ISS) Q2Q1W2 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
5 | O70277 (/IDA) P13466 (/IDA) P13466 (/IDA) Q9C040 (/IDA) Q9R1R2 (/IDA) |
|
Phagocytic cup GO:0001891
An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
2 | P13466 (/IDA) P13466 (/IDA) |
|
P-body GO:0000932
A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing.
|
1 | Q1PSW8 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9H8W5 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q6PFY8 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9ESN6 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9ESN6 (/NAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O75382 (/TAS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9H8W5 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q6PFY8 (/ISO) |
|
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
|
1 | Q9H8W5 (/IDA) |
|
Intercellular bridge GO:0045171
A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised.
|
1 | Q6PFY8 (/ISO) |