The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 136068: Light chain variable region

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
31 P01593 (/NAS) P01594 (/NAS) P01597 (/NAS) P01599 (/NAS) P01601 (/NAS) P01602 (/NAS) P01611 (/NAS) P01614 (/NAS) P01615 (/NAS) P01619 (/NAS)
(21 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q6PIK1 (/IPI) Q6PIQ7 (/IPI) Q8N355 (/IPI)

There are 11 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
40 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(30 more)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
40 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(30 more)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Fc-epsilon receptor signaling pathway GO:0038095
A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
39 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(29 more)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
31 P01593 (/NAS) P01594 (/NAS) P01597 (/NAS) P01599 (/NAS) P01601 (/NAS) P01602 (/NAS) P01611 (/NAS) P01614 (/NAS) P01615 (/NAS) P01619 (/NAS)
(21 more)
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
1 P01619 (/IMP)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
1 P01619 (/IDA)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
40 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(30 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
37 A0A075B6P5 (/TAS) A0A075B6S6 (/TAS) A0A0C4DH25 (/TAS) A0A0C4DH73 (/TAS) A2NXD2 (/TAS) P01593 (/TAS) P01594 (/TAS) P01597 (/TAS) P01599 (/TAS) P01601 (/TAS)
(27 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
31 P01593 (/NAS) P01594 (/NAS) P01597 (/NAS) P01599 (/NAS) P01601 (/NAS) P01602 (/NAS) P01611 (/NAS) P01614 (/NAS) P01615 (/NAS) P01619 (/NAS)
(21 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
23 P01593 (/IDA) P01594 (/IDA) P01597 (/IDA) P01599 (/IDA) P01601 (/IDA) P01602 (/IDA) P01611 (/IDA) P01614 (/IDA) P01615 (/IDA) P01619 (/IDA)
(13 more)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
16 P01593 (/IDA) P01594 (/IDA) P01597 (/IDA) P01599 (/IDA) P01602 (/IDA) P01611 (/IDA) P01614 (/IDA) P01615 (/IDA) P01619 (/IDA) P01624 (/IDA)
(6 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P01619 (/IDA)
Monomeric IgA immunoglobulin complex GO:0071748
A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph.
1 P01619 (/IDA)
Secretory IgA immunoglobulin complex GO:0071751
A polymeric IgA immunoglobulin complex that is complexed with one chain of secretory component (SC). Polymeric IgA is present in mucosal areas, having been transported via a transcytosis mechanism in mucosal epithelial cells relying on the polymeric Ig receptor, a portion of which then remains bound to the polymeric IgA as secretory component.
1 P01619 (/IDA)
Pentameric IgM immunoglobulin complex GO:0071756
A circulating form of IgM consisting of a pentamer of IgM core units with a single J chain polypeptide.
1 P01619 (/IDA)