Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.

Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.

A defense response that is mediated by cells.

Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.

Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-dependent toll-like receptor signaling pathway.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that stops, prevents, or reduces the rate of mast cell degranulation.

Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway.

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance.

Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance.

The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other.

Any process involved in the carrying out of an immune response by a neutrophil.

The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.

The regulated release of serotonin by a mast cell or group of mast cells.

An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.

The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.

The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.

The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.

Any process that stops, prevents or reduces the rate or extent of B cell proliferation.

Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.

Any process that activates or increases the activity of a phosphoprotein phosphatase.

Any process that activates or increases the activity of a phosphoprotein phosphatase.

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

Any process that modulates the frequency, rate, or extent of tumor necrosis factor production.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.

Any process that activates or increases the frequency, rate, or extent of mast cell activation.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.

Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Any process that activates or increases the frequency, rate, or extent of toll-like receptor 9 signaling pathway.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.

A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

Any process that stops, prevents, or reduces the rate of mast cell degranulation.

The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

Any process that stops, prevents, or reduces the frequency, rate or extent of multiplication or reproduction of fibroblast cells.

Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell.

Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell.

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation.

Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation.

Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

Any process that stops, prevents, or reduces the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.

Any process that activates or increases the frequency, rate or extent of interleukin-4-mediated signaling pathway.

Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation.

Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil activation.

Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation.

Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil activation.

Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK2 kinase activity.

Any process that stops, prevents or reduces the frequency, rate or extent of activation of JAK2 kinase activity.

Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration.

Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration.

Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance.

Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance.

Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.

The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

A vacuole to which materials ingested by endocytosis are delivered.

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

The region of the plasma membrane located at the apical end of the cell.

The lipid bilayer surrounding a tertiary granule.

The lipid bilayer surrounding a ficolin-1-rich granule.