The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 133851: Fibroblast growth factor receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 18 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P22455 (/IPI) Q03142 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 Q03142 (/ISS) Q498D6 (/ISS)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
2 Q03142 (/ISS) Q498D6 (/ISS)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 P22455 (/TAS)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P22455 (/IDA)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P22455 (/IGI)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q498D6 (/IPI)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q03142 (/ISO)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 Q03142 (/ISS)
Fibroblast growth factor-activated receptor activity GO:0005007
Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
1 P22455 (/TAS)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 P22455 (/TAS)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 P22455 (/IDA)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 Q03142 (/ISO)
1-phosphatidylinositol-3-kinase activity GO:0016303
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).
1 P22455 (/TAS)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 P22455 (/IDA)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 P22455 (/IPI)
Fibroblast growth factor binding GO:0017134
Interacting selectively and non-covalently with a fibroblast growth factor.
1 Q03142 (/ISO)
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
1 P22455 (/TAS)

There are 59 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P22455 (/IGI) Q03142 (/IGI)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 Q03142 (/ISS) Q498D6 (/ISS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2 P22455 (/IGI) Q03142 (/IGI)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2 P22455 (/IPI) Q498D6 (/IPI)
Regulation of extracellular matrix disassembly GO:0010715
Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
2 Q03142 (/ISS) Q498D6 (/ISS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
2 Q03142 (/ISS) Q498D6 (/ISS)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
2 Q03142 (/ISS) Q498D6 (/ISS)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
2 P22455 (/ISS) Q498D6 (/ISS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
2 P22455 (/ISS) Q498D6 (/ISS)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
2 Q03142 (/ISS) Q498D6 (/ISS)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
2 Q03142 (/ISS) Q498D6 (/ISS)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 Q03142 (/ISS) Q498D6 (/ISS)
Phosphate ion homeostasis GO:0055062
Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.
2 P22455 (/ISS) Q498D6 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q03142 (/ISS) Q498D6 (/ISS)
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
2 P22455 (/IMP) Q03142 (/IMP)
Regulation of cholesterol homeostasis GO:2000188
Any process that modulates the frequency, rate or extent of cholesterol homeostasis.
2 P22455 (/ISS) Q498D6 (/ISS)
Positive regulation of DNA biosynthetic process GO:2000573
Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
2 Q03142 (/ISS) Q498D6 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 P22455 (/TAS)
Organ induction GO:0001759
The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ.
1 Q03142 (/IMP)
Vacuolar phosphate transport GO:0007037
The directed movement of phosphates into, out of or within a vacuole.
1 Q03142 (/IGI)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P22455 (/IDA)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q03142 (/ISO)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 P22455 (/IDA)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q03142 (/ISO)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 Q03142 (/ISS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
1 P22455 (/TAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P22455 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q03142 (/ISO)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q03142 (/IGI)
Regulation of extracellular matrix disassembly GO:0010715
Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
1 P22455 (/IMP)
Regulation of extracellular matrix disassembly GO:0010715
Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
1 Q03142 (/ISO)
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 P22455 (/TAS)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 P22455 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q03142 (/ISO)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 P22455 (/IDA)
Peptidyl-tyrosine phosphorylation GO:0018108
The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine.
1 Q03142 (/ISO)
Regulation of lipid metabolic process GO:0019216
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
1 Q03142 (/IMP)
Lung development GO:0030324
The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax.
1 Q03142 (/IMP)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
1 Q03142 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
1 P22455 (/IMP)
Positive regulation of catalytic activity GO:0043085
Any process that activates or increases the activity of an enzyme.
1 Q03142 (/ISO)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 P22455 (/IMP)
Positive regulation of proteolysis GO:0045862
Any process that activates or increases the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 Q03142 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P22455 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q03142 (/ISO)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 P22455 (/TAS)
Regulation of phosphorus metabolic process GO:0051174
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus.
1 Q03142 (/IGI)
Phosphate ion homeostasis GO:0055062
Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.
1 Q03142 (/IMP)
Alveolar secondary septum development GO:0061144
The progression of a secondary alveolar septum over time, from its formation to the mature structure. A secondary alveolar septum is a specialized epithelium that subdivides the initial saccule.
1 Q03142 (/IGI)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 P22455 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q03142 (/ISO)
Vitamin D3 metabolic process GO:0070640
The chemical reactions and pathways involving vitamin D3, (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol.
1 Q03142 (/IGI)
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
1 Q03142 (/ISO)
Regulation of bile acid biosynthetic process GO:0070857
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids.
1 Q498D6 (/ISS)
Negative regulation of fibroblast growth factor production GO:0090272
Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 Q03142 (/IGI)
Regulation of cholesterol homeostasis GO:2000188
Any process that modulates the frequency, rate or extent of cholesterol homeostasis.
1 Q03142 (/IMP)
Positive regulation of DNA biosynthetic process GO:2000573
Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
1 P22455 (/IMP)
Positive regulation of DNA biosynthetic process GO:2000573
Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process.
1 Q03142 (/ISO)
Positive regulation of parathyroid hormone secretion GO:2000830
Any process that activates or increases the frequency, rate or extent of parathyroid hormone secretion.
1 Q03142 (/IGI)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
2 Q03142 (/ISS) Q498D6 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q03142 (/ISS) Q498D6 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 P22455 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 Q03142 (/ISO)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 P22455 (/IDA)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
1 Q03142 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P22455 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q03142 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P22455 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P22455 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q03142 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P22455 (/TAS)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 P22455 (/IDA)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
1 Q03142 (/ISO)