The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Alpha-ketoglutarate-dependent dioxygenase AlkB-like
".
FunFam 2423: Putative RNA replicase
There are 4 EC terms in this cluster
Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
EC Term | Annotations | Evidence |
---|---|---|
RNA-directed RNA polymerase.
[EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
|
8 | A0AUJ5 B1PS76 K4NQ76 O71189 P20951 Q04575 Q64962 Q91QZ3 |
RNA helicase.
[EC: 3.6.4.13]
ATP + H(2)O = ADP + phosphate.
|
8 | B1PS76 K4NQ76 O71188 O71189 P20951 Q04575 Q64962 Q91QZ3 |
Nuclear-inclusion-a endopeptidase.
[EC: 3.4.22.44]
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
|
1 | A0AUJ5 |
Helper-component proteinase.
[EC: 3.4.22.45]
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.
|
1 | A0AUJ5 |