The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2398: Alkylated DNA repair protein AlkB

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA oxidative demethylase. [EC:]
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
  • Activity is slightly stimulated by ascorbate.
  • Catalyzes oxidative demethylation of the DNA base lesions N(1)- methyladenine, N(3)-methylcytosine, N(1)-methylguanine, and N(3)- methylthymine.
  • It works better on single-stranded DNA (ssDNA) and is capable of repairing damaged bases in RNA.
59 A0A021XAR9 A0A037Y4V1 A0A069XS00 A0A070T6Z4 A0A0C7KCM9 A0A0D6FCQ6 A0A0E9B8T8 A0A0E9BZ02 A0A0F6B3Z4 A0A0F7JA11
(49 more...)
Stearoyl-CoA 9-desaturase. [EC:]
Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
  • The liver enzyme is an enzyme system involving cytochrome b5 and EC
  • The ferricytochrome b5 produced is reduced by NADH and EC
  • Formerly EC
1 G8QAH6