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CATH Superfamily 2.60.120.40

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2614: Complement C1q subcomponent subunit C

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 20 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
 11 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q95JD7 (/ISS)
(1 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
 11 A8K660 (/IPI) B2RNN3 (/IPI) P02745 (/IPI) P0C862 (/IPI) P27658 (/IPI) P98086 (/IPI) Q03692 (/IPI) Q15848 (/IPI) Q4VAQ0 (/IPI) Q60994 (/IPI)
(1 more)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
 4 A0A0G2K845 (/IDA) Q15848 (/IDA) Q60994 (/IDA) Q8K3R4 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 3 P0C862 (/IPI) Q3Y5Z3 (/IPI) Q60994 (/IPI)
Serine-type endopeptidase activity GO:0004252
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
 2 P02745 (/TAS) P02747 (/TAS)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 2 Q60994 (/IDA) Q9D8U4 (/IDA)
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
 2 Q15848 (/IDA) Q3Y5Z3 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 2 Q8K479 (/IDA) Q9D8U4 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
 1 Q15848 (/NAS)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
 1 Q60994 (/ISO)
Hormone activity GO:0005179
The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process.
 1 Q60994 (/TAS)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
 1 P25067 (/NAS)
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
 1 A0A0G2K7A5 (/TAS)
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
 1 P25067 (/NAS)
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
 1 Q60994 (/ISO)
Sialic acid binding GO:0033691
Interacting selectively and non-covalently with sialic acid, any of a variety of N- or O- substituted derivatives of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria.
 1 X4ZFS1 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
 1 Q15848 (/TAS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
 1 Q15848 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
 1 Q60994 (/ISO)

There are 209 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of protein kinase A signaling GO:0010739
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of macrophage derived foam cell differentiation GO:0010745
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of granulocyte differentiation GO:0030853
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of myeloid cell apoptotic process GO:0033034
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of macrophage differentiation GO:0045650
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of fatty acid metabolic process GO:0045923
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Detection of oxidative stress GO:0070994
The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of monocyte chemotactic protein-1 production GO:0071639
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of intracellular protein transport GO:0090317
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Positive regulation of metanephric glomerular visceral epithelial cell development GO:2000478
Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of metanephric mesenchymal cell migration GO:2000590
Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration.
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q8K3R4 (/ISS)
(2 more)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(2 more)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q8K3R4 (/ISS)
(2 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q8K3R4 (/ISS)
(2 more)
Positive regulation of glycogen (starch) synthase activity GO:2000467
Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS)
(2 more)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q8K3R4 (/ISS)
(2 more)
Positive regulation of renal albumin absorption GO:2000534
Any process that activates or increases the frequency, rate or extent of renal albumin absorption.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q8K3R4 (/ISS)
(2 more)
Protein homooligomerization GO:0051260
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
 5 A0A0G2K845 (/IDA) Q60994 (/IDA) Q8BVD7 (/IDA) Q8K3R4 (/IDA) Q9D8U4 (/IDA)
Complement activation GO:0006956
Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
 4 E1BSP0 (/TAS) F1NH19 (/TAS) P02745 (/TAS) P02747 (/TAS)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
 4 E1BSP0 (/TAS) F1NH19 (/TAS) P02745 (/TAS) P02747 (/TAS)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
 3 P25067 (/TAS) P27658 (/TAS) Q03692 (/TAS)
Collagen catabolic process GO:0030574
The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells.
 3 P25067 (/TAS) P27658 (/TAS) Q03692 (/TAS)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
 2 F1QFM5 (/IDA) F1RAV1 (/IDA)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Response to sucrose GO:0009744
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
 2 Q15848 (/IDA) Q60994 (/IDA)
Notochord formation GO:0014028
The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column.
 2 B0S5W0 (/IMP) B7SW26 (/IMP)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
 2 A0A0G2K845 (/NAS) Q8K3R4 (/NAS)
Regulation of complement activation GO:0030449
Any process that modulates the frequency, rate or extent of complement activation.
 2 P02745 (/TAS) P02747 (/TAS)
Negative regulation of granulocyte differentiation GO:0030853
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
 2 P02747 (/IDA) Q15848 (/IDA)
Negative regulation of granulocyte differentiation GO:0030853
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
 2 Q02105 (/ISO) Q60994 (/ISO)
Notochord development GO:0030903
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
 2 B0S5W0 (/IMP) B7SW26 (/IMP)
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Adiponectin-activated signaling pathway GO:0033211
A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Response to ethanol GO:0045471
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
 2 Q15848 (/IDA) Q60994 (/IDA)
Negative regulation of macrophage differentiation GO:0045650
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.
 2 P02747 (/IDA) Q15848 (/IDA)
Negative regulation of macrophage differentiation GO:0045650
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage differentiation.
 2 Q02105 (/ISO) Q60994 (/ISO)
Positive regulation of blood pressure GO:0045777
Any process in which the force of blood traveling through the circulatory system is increased.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
 2 Q60994 (/IDA) Q9D8U4 (/IDA)
Negative regulation of hormone secretion GO:0046888
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Notochord morphogenesis GO:0048570
The process in which the anatomical structures of the notochord are generated and organized. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.
 2 B0S5W0 (/IMP) B7SW26 (/IMP)
Camera-type eye morphogenesis GO:0048593
The process in which the anatomical structures of the eye are generated and organized. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
 2 P25318 (/IGI) Q00780 (/IGI)
Epithelial cell proliferation GO:0050673
The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances.
 2 P25318 (/IGI) Q00780 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Membrane depolarization GO:0051899
The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Head development GO:0060322
The biological process whose specific outcome is the progression of a head from an initial condition to its mature state. The head is the anterior-most division of the body.
 2 B0S5W0 (/IMP) B7SW26 (/IMP)
Protein trimerization GO:0070206
The formation of a protein trimer, a macromolecular structure consisting of three noncovalently associated identical or nonidentical subunits.
 2 Q8K479 (/IDA) Q9D8U4 (/IDA)
Protein heterotrimerization GO:0070208
The formation of a protein heterotrimer, a macromolecular structure consisting of three noncovalently associated subunits, of which not all are identical.
 2 Q60994 (/IPI) Q9D8U4 (/IPI)
Response to linoleic acid GO:0070543
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a linoleic acid stimulus.
 2 A0A0G2K845 (/IEP) Q8K3R4 (/IEP)
Cellular response to cAMP GO:0071320
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
 1 Q9D8U4 (/IDA)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
 1 Q03692 (/TAS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
 1 Q15848 (/IDA)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
 1 Q60994 (/ISO)
Endochondral ossification GO:0001958
Replacement ossification wherein bone tissue replaces cartilage.
 1 A0A0G2K7A5 (/IMP)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
 1 Q60994 (/IDA)
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
 1 Q60994 (/IMP)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
 1 Q15848 (/TAS)
Fatty acid beta-oxidation GO:0006635
A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
 1 Q60994 (/IMP)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
 1 P02747 (/NAS)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
 1 P98086 (/IMP)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
 1 P02745 (/TAS)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
 1 Q8K479 (/IMP)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
 1 Q60994 (/IDA)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
 1 Q60994 (/IMP)
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
 1 Q60994 (/IDA)
Response to iron ion GO:0010039
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
 1 P31720 (/IEP)
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
 1 Q60994 (/ISO)
Positive regulation of protein kinase A signaling GO:0010739
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
 1 Q15848 (/IDA)
Positive regulation of protein kinase A signaling GO:0010739
Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound.
 1 Q60994 (/ISO)
Negative regulation of macrophage derived foam cell differentiation GO:0010745
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
 1 Q15848 (/IDA)
Negative regulation of macrophage derived foam cell differentiation GO:0010745
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
 1 Q60994 (/ISO)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
 1 Q15848 (/IDA)
Negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804
Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.
 1 Q60994 (/ISO)
Positive regulation of cell-substrate adhesion GO:0010811
Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
 1 Q00780 (/IDA)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
 1 Q15848 (/IDA)
Positive regulation of cholesterol efflux GO:0010875
Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
 1 Q60994 (/ISO)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
 1 Q15848 (/IDA)
Regulation of glucose metabolic process GO:0010906
Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
 1 Q60994 (/ISO)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
 1 Q15848 (/IDA)
Negative regulation of smooth muscle cell migration GO:0014912
Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.
 1 Q60994 (/ISO)
Single organismal cell-cell adhesion GO:0016337
The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism.
 1 P25067 (/NAS)
Fatty acid oxidation GO:0019395
The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen.
 1 Q60994 (/IDA)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
 1 P25067 (/NAS)
Negative regulation of cell migration GO:0030336
Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration.
 1 Q60994 (/IDA)
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
 1 Q15848 (/IDA)
Negative regulation of protein autophosphorylation GO:0031953
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.
 1 Q60994 (/ISO)
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
 1 Q15848 (/IDA)
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
 1 Q60994 (/ISO)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
 1 Q15848 (/IDA)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
 1 Q60994 (/ISO)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
 1 Q15848 (/IDA)
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
 1 Q60994 (/ISO)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
 1 Q60994 (/IGI)
Positive regulation of myeloid cell apoptotic process GO:0033034
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.
 1 Q15848 (/IDA)
Positive regulation of myeloid cell apoptotic process GO:0033034
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.
 1 Q60994 (/ISO)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
 1 Q15848 (/IDA)
Negative regulation of heterotypic cell-cell adhesion GO:0034115
Any process that stops, prevents, or reduces the frequency, rate, or extent of heterotypic cell-cell adhesion.
 1 Q60994 (/ISO)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
 1 Q15848 (/IDA)
Low-density lipoprotein particle clearance GO:0034383
The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
 1 Q60994 (/ISO)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
 1 Q15848 (/IDA)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
 1 Q60994 (/ISO)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
 1 Q60994 (/IDA)
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
 1 P27658 (/IEP)
Regulation of fatty acid biosynthetic process GO:0042304
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils.
 1 Q15848 (/TAS)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
 1 Q60994 (/IDA)
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
 1 Q60994 (/IMP)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
 1 Q60994 (/IDA)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
 1 Q15848 (/IDA)
Negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124
Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling.
 1 Q60994 (/ISO)
Negative regulation of MAP kinase activity GO:0043407
Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.
 1 Q60994 (/IDA)
Otolith mineralization GO:0045299
The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear.
 1 P83371 (/NAS)
Negative regulation of fat cell differentiation GO:0045599
Any process that stops, prevents, or reduces the frequency, rate or extent of adipocyte differentiation.
 1 Q60994 (/ISO)
Negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
 1 Q15848 (/IDA)
Negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.
 1 Q60994 (/ISO)
Negative regulation of gluconeogenesis GO:0045721
Any process that stops, prevents, or reduces the frequency, rate or extent of gluconeogenesis.
 1 Q60994 (/IDA)
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
 1 Q9D8U4 (/IDA)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
 1 Q15848 (/IDA)
Negative regulation of blood pressure GO:0045776
Any process in which the force of blood traveling through the circulatory system is decreased.
 1 Q60994 (/ISO)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
 1 Q8K3R4 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 1 Q15848 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 1 Q60994 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
 1 Q60994 (/ISO)
Positive regulation of fatty acid metabolic process GO:0045923
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving fatty acids.
 1 Q60994 (/IMP)
Positive regulation of fatty acid oxidation GO:0046321
Any process that activates or increases the frequency, rate or extent of fatty acid oxidation.
 1 Q9D8U4 (/IDA)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
 1 Q15848 (/IDA)
Negative regulation of smooth muscle cell proliferation GO:0048662
Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.
 1 Q60994 (/ISO)
Inner ear development GO:0048839
The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure.
 1 Q8K479 (/IDA)
Otolith development GO:0048840
The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.
 1 A5PN28 (/IMP)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
 1 Q60994 (/IDA)
Negative regulation of inflammatory response GO:0050728
Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response.
 1 Q15848 (/NAS)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
 1 Q15848 (/IDA)
Negative regulation of phagocytosis GO:0050765
Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis.
 1 Q60994 (/ISO)
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
 1 Q15848 (/IDA)
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
 1 Q60994 (/ISO)
Brown fat cell differentiation GO:0050873
The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.
 1 Q60994 (/IDA)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
 1 A0A0G2K7A5 (/IMP)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
 1 F1QFM5 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
 1 Q15848 (/IDA)
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
 1 Q60994 (/ISO)
Detection of oxidative stress GO:0070994
The series of events in which a stimulus indicating oxidative stress is received and converted into a molecular signal.
 1 Q60994 (/IMP)
Positive regulation of monocyte chemotactic protein-1 production GO:0071639
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
 1 Q15848 (/IDA)
Positive regulation of monocyte chemotactic protein-1 production GO:0071639
Any process that activates or increases the frequency, rate, or extent of production of monocyte chemotactic protein-1.
 1 Q60994 (/ISO)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
 1 Q15848 (/IDA)
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
 1 Q60994 (/ISO)
Negative regulation of intracellular protein transport GO:0090317
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
 1 Q15848 (/IDA)
Negative regulation of intracellular protein transport GO:0090317
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.
 1 Q60994 (/ISO)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
 1 Q15848 (/IDA)
Negative regulation of receptor binding GO:1900121
Any process that stops, prevents or reduces the frequency, rate or extent of a protein or other molecule binding to a receptor.
 1 Q60994 (/ISO)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
 1 Q15848 (/IDA)
Negative regulation of DNA biosynthetic process GO:2000279
Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process.
 1 Q60994 (/ISO)
Positive regulation of glycogen (starch) synthase activity GO:2000467
Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity.
 1 Q8K3R4 (/IDA)
Positive regulation of metanephric glomerular visceral epithelial cell development GO:2000478
Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development.
 1 Q60994 (/IMP)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
 1 Q15848 (/IDA)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
 1 Q60994 (/IMP)
Positive regulation of cAMP-dependent protein kinase activity GO:2000481
Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity.
 1 Q60994 (/ISO)
Positive regulation of renal albumin absorption GO:2000534
Any process that activates or increases the frequency, rate or extent of renal albumin absorption.
 1 Q15848 (/IDA)
Positive regulation of renal albumin absorption GO:2000534
Any process that activates or increases the frequency, rate or extent of renal albumin absorption.
 1 Q60994 (/IMP)
Positive regulation of renal albumin absorption GO:2000534
Any process that activates or increases the frequency, rate or extent of renal albumin absorption.
 1 Q60994 (/ISO)
Negative regulation of platelet-derived growth factor receptor-alpha signaling pathway GO:2000584
Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway.
 1 Q60994 (/IDA)
Negative regulation of metanephric mesenchymal cell migration GO:2000590
Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration.
 1 Q60994 (/IDA)

There are 40 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
 13 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q15848 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(3 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 12 A0A0G2K845 (/IDA) P02747 (/IDA) P98086 (/IDA) Q00780 (/IDA) Q02105 (/IDA) Q15848 (/IDA) Q3Y5Z3 (/IDA) Q60994 (/IDA) Q8BVD7 (/IDA) Q8K3R4 (/IDA)
(2 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(2 more)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(2 more)
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
 12 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q60994 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS)
(2 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 11 A4PB30 (/ISS) B1Q3K7 (/ISS) C9DFG2 (/ISS) D2H071 (/ISS) Q2LDA4 (/ISS) Q2TIL1 (/ISS) Q3Y5Z3 (/ISS) Q6PP07 (/ISS) Q76C76 (/ISS) Q95JD7 (/ISS)
(1 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 10 E1BSP0 (/TAS) F1NH19 (/TAS) P02745 (/TAS) P02747 (/TAS) P08125 (/TAS) P23206 (/TAS) P25067 (/TAS) P27658 (/TAS) Q03692 (/TAS) Q15848 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 6 B2RNN3 (/IDA) P02745 (/IDA) P02747 (/IDA) P27658 (/IDA) Q15848 (/IDA) Q9BXJ0 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
 6 P98086 (/ISO) Q00780 (/ISO) Q02105 (/ISO) Q4ZJN1 (/ISO) Q60994 (/ISO) Q8K479 (/ISO)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
 3 P25067 (/TAS) P27658 (/TAS) Q03692 (/TAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 2 P83371 (/IDA) Q8K479 (/IDA)
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
 2 A0A0G2K7A5 (/IDA) Q05306 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
 2 Q02105 (/ISO) Q60994 (/ISO)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
 2 A0A060WQA3 (/IDA) Q3Y5Z3 (/IDA)
Protein complex GO:0043234
A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.
 2 A0A0G2K845 (/IDA) Q8K3R4 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
 1 P02747 (/NAS)
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
 1 P25067 (/NAS)
Collagen trimer GO:0005581
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
 1 Q05306 (/IDA)
Collagen trimer GO:0005581
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.
 1 Q03692 (/TAS)
Collagen type VIII trimer GO:0005591
A collagen heterotrimer containing type VIII alpha chains;
 1 P27658 (/TAS)
Complement component C1 complex GO:0005602
A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains.
 1 P02745 (/TAS)
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
 1 P25067 (/NAS)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
 1 P83371 (/ISS)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
 1 Q60994 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
 1 Q8K479 (/IDA)
Bicellular tight junction GO:0005923
An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes.
 1 Q8K479 (/IDA)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
 1 Q05306 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 1 Q15848 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
 1 Q60994 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
 1 Q8K479 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
 1 Q8K479 (/IDA)
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
 1 Q8K479 (/IDA)
Transport vesicle GO:0030133
Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell.
 1 Q8K479 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
 1 P27658 (/IDA)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
 1 Q00780 (/ISO)
Cell projection GO:0042995
A prolongation or process extending from a cell, e.g. a flagellum or axon.
 1 Q8K479 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 1 P08125 (/IDA)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
 1 Q05306 (/ISO)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
 1 P02747 (/IDA)
Blood microparticle GO:0072562
A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids.
 1 Q02105 (/ISO)