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CATH Superfamily 2.60.120.330

B-lactam Antibiotic, Isopenicillin N Synthase; Chain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
B-lactam Antibiotic, Isopenicillin N Synthase; Chain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5236: L-proline cis-3-hydroxylase 2

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Proline 3-hydroxylase. [EC: 1.14.11.28]
L-proline + 2-oxoglutarate + O(2) = cis-3-hydroxy-L-proline + succinate + CO(2).
  • Unlike the proline hydroxylases involved in collagen biosynthesis (EC 1.14.11.2 and EC 1.14.11.7), this enzyme does not require ascorbate for activity although it does increase the activity of the enzyme.
  • The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L- proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not substrates.
 4 O09345 O09345 P96010 P96010