CATH Superfamily 2.60.120.200
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 20166: Crumbs, isoform D
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
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1 | P10040 (/IPI) |
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Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
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1 | P10040 (/IPI) |
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Spectrin binding GO:0030507
Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers.
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1 | P10040 (/TAS) |
There are 54 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Morphogenesis of a polarized epithelium GO:0001738
The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
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1 | P10040 (/TAS) |
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Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
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1 | P10040 (/IGI) |
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Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
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1 | P10040 (/IMP) |
|
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
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1 | P10040 (/NAS) |
|
Morphogenesis of an epithelium GO:0002009
The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube.
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1 | P10040 (/TAS) |
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Cell-cell junction assembly GO:0007043
The aggregation, arrangement and bonding together of a set of components to form a junction between cells.
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1 | P10040 (/NAS) |
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Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
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1 | P10040 (/IMP) |
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Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
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1 | P10040 (/NAS) |
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Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
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1 | P10040 (/IMP) |
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Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
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1 | P10040 (/IMP) |
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Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
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1 | P10040 (/IMP) |
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Salivary gland development GO:0007431
The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.
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1 | P10040 (/TAS) |
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Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
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1 | P10040 (/IMP) |
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Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
|
1 | P10040 (/IMP) |
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Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
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1 | P10040 (/TAS) |
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Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
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1 | P10040 (/IMP) |
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Establishment or maintenance of polarity of embryonic epithelium GO:0016332
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo.
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1 | P10040 (/IMP) |
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Establishment or maintenance of polarity of follicular epithelium GO:0016334
Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet.
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1 | P10040 (/IMP) |
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Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
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1 | P10040 (/IGI) |
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Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
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1 | P10040 (/IMP) |
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Regulation of intracellular protein transport GO:0033157
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.
|
1 | P10040 (/IMP) |
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Adherens junction organization GO:0034332
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
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1 | P10040 (/IMP) |
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Liquid clearance, open tracheal system GO:0035002
The clearance of liquid from the epithelial tubes of an open tracheal system, shortly before the emergence of the larva, to generate an air-filled tubule system.
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1 | P10040 (/IGI) |
|
Establishment or maintenance of apical/basal cell polarity GO:0035088
Any cellular process that results in the specification, formation or maintenance polarization of a cell's architecture along its apical/basal axis so that the apical and basal regions of the cell have different membrane, extracellular matrix and sub-membrane cellular components.
|
1 | P10040 (/IMP) |
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Maintenance of apical/basal cell polarity GO:0035090
Retaining the established polarization of a cell along its apical/basal axis.
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1 | P10040 (/IMP) |
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Tube morphogenesis GO:0035239
The process in which the anatomical structures of a tube are generated and organized. Epithelial and endothelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system.
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1 | P10040 (/IMP) |
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Regulation of hippo signaling GO:0035330
Any process that modulates the frequency, rate or extent of hippo signaling.
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1 | P10040 (/IGI) |
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Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
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1 | P10040 (/IMP) |
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Compound eye photoreceptor development GO:0042051
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.
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1 | P10040 (/TAS) |
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Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
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1 | P10040 (/IMP) |
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Rhabdomere development GO:0042052
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
|
1 | P10040 (/NAS) |
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Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
|
1 | P10040 (/IMP) |
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Cuticle development GO:0042335
The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss.
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1 | P10040 (/IGI) |
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Zonula adherens assembly GO:0045186
Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
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1 | P10040 (/IMP) |
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Zonula adherens assembly GO:0045186
Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
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1 | P10040 (/TAS) |
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Establishment or maintenance of epithelial cell apical/basal polarity GO:0045197
Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.
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1 | P10040 (/TAS) |
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Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
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1 | P10040 (/TAS) |
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Zonula adherens maintenance GO:0045218
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
|
1 | P10040 (/IMP) |
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Zonula adherens maintenance GO:0045218
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
|
1 | P10040 (/NAS) |
|
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
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1 | P10040 (/IMP) |
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Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
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1 | P10040 (/NAS) |
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Regulation of imaginal disc growth GO:0045570
Any process that modulates the frequency, rate or extent of the growth of the imaginal disc.
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1 | P10040 (/IMP) |
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Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
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1 | P10040 (/IGI) |
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Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
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1 | P10040 (/IMP) |
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Dorsal closure, amnioserosa morphology change GO:0046664
The changes that occur during dorsal closure of the shape and structure of the amnioserosa, an epithelium that occupies the dorsal side of the embryo.
|
1 | P10040 (/IMP) |
|
Amnioserosa maintenance GO:0046665
Maintenance of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis.
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1 | P10040 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
1 | P10040 (/IMP) |
|
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
|
1 | P10040 (/IMP) |
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Centrosome localization GO:0051642
Any process in which a centrosome is transported to, and/or maintained in, a specific location within the cell.
|
1 | P10040 (/IMP) |
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Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
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1 | P10040 (/IMP) |
|
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
|
1 | P10040 (/TAS) |
|
Cell morphogenesis involved in Malpighian tubule morphogenesis GO:0061336
The shape change of an epithelial cell from a columnar to squamous cell morphology that contributes to the shaping of the Malpighian tubule.
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1 | P10040 (/IMP) |
|
Rhabdomere morphogenesis GO:0061541
The process in which the anatomical structures of a rhabdomere are generated and organized. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.
|
1 | P10040 (/IMP) |
|
Nuclear chromosome segregation GO:0098813
The process in which genetic material, in the form of nuclear chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. Nuclear chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
1 | P10040 (/IMP) |
There are 11 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P10040 (/IDA) |
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Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P10040 (/ISS) |
|
Septate junction GO:0005918
A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates.
|
1 | P10040 (/TAS) |
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Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
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1 | P10040 (/TAS) |
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Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
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1 | P10040 (/IDA) |
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Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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1 | P10040 (/IDA) |
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Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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1 | P10040 (/NAS) |
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Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
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1 | P10040 (/TAS) |
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Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
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1 | P10040 (/IDA) |
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Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
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1 | P10040 (/IPI) |
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Subapical complex GO:0035003
The most apical region of the lateral plasma membrane of an invertebrate epithelial cell. The subapical complex lies above the zonula adherens and the septate junction, and is comparable to the position of the tight junction of vertebrate cells.
|
1 | P10040 (/TAS) |