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CATH Superfamily 2.60.120.10

Jelly Rolls

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54736: Putative mannose-1-phosphate guanylyltransferase/m...

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Mannose-1-phosphate guanylyltransferase. [EC: 2.7.7.13]
GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
  • The bacterial enzyme can also use ITP and dGTP as donors.
 1354 A0A011NY85 A0A011P0Q4 A0A011PCR5 A0A011QHR8 A0A011RAR8 A0A011TSC9 A0A014NKN6 A0A016XDZ3 A0A017IEK1 A0A021X3B1
(1344 more...)
Mannose-1-phosphate guanylyltransferase (GDP). [EC: 2.7.7.22]
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose.
    		 825 A0A017H8B3 A0A017HLR4 A0A017IEK1 A0A023YZI0 A0A024K8V7 A0A024L127 A0A025CGT6 A0A026V0W4 A0A027TWV9 A0A028E4R5
    (815 more...)
    Mannose-6-phosphate isomerase. [EC: 5.3.1.8]
    D-mannose 6-phosphate = D-fructose 6-phosphate.
      		 552 A0A017IEK1 A0A024HCW7 A0A024HQL6 A0A026V0W4 A0A027TWV9 A0A029HXZ3 A0A029IS27 A0A029L981 A0A029LK31 A0A029PI99
      (542 more...)
      Tetraacyldisaccharide 4'-kinase. [EC: 2.7.1.130]
      ATP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl)- (1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-4-O-phospho- beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)- alpha-D-glucosaminyl phosphate).
      • Involved with EC 2.3.1.129 and 2.4.1.182 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
      		 2 A0A176NQ48 G8QA20
      Phosphomannomutase. [EC: 5.4.2.8]
      Alpha-D-mannose 1-phosphate = D-mannose 6-phosphate.
      • Alpha-D-mannose 1,6-bisphosphate or alpha-D-glucose 1,6-bisphosphate can act as cofactor.
      • Formerly EC 2.7.5.7.
      		 1 Q1MD16
      FAD synthetase. [EC: 2.7.7.2]
      ATP + FMN = diphosphate + FAD.
      • Highly specific for ATP as phosphate donor.
      • The cofactors FMN and FAD participate in numerous processes in all organisms, including mitochondrial electron transport, photosynthesis, fatty-acid oxidation, and metabolism of vitamin B6, vitamin B12 and folates.
      • While monofunctional FAD synthetase is found in eukaryotes and in some prokaryotes, most prokaryotes have a bifunctional enzyme that exhibits both this activity and that of EC 2.7.1.26.
      		 1 Q2LWM2
      GDP-L-fucose synthase. [EC: 1.1.1.271]
      GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
      • Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.
      		 1 W7X1J9
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