The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54693: Neuropathy target esterase sws

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
2 A2AJ88 (/EXP) Q8IY17 (/EXP)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
2 A2AJ88 (/IDA) Q9U969 (/IDA)
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
2 F1R844 (/ISS) Q3TRM4 (/ISS)
Lysophospholipase activity GO:0004622
Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.
1 Q3TRM4 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9U969 (/IPI)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
1 Q9U969 (/IPI)
Carboxylic ester hydrolase activity GO:0052689
Catalysis of the hydrolysis of a carboxylic ester bond.
1 Q5BK26 (/IMP)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane lipid metabolic process GO:0006643
The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Glial cell apoptotic process GO:0034349
Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Glycerophospholipid catabolic process GO:0046475
The chemical reactions and pathways resulting in the breakdown of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
2 A2AJ88 (/TAS) Q8IY17 (/TAS)
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
1 Q3TRM4 (/IMP)
Membrane lipid metabolic process GO:0006643
The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane.
1 Q9U969 (/IDA)
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
1 Q9U969 (/IMP)
Ensheathment of neurons GO:0007272
The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.
1 Q9U969 (/IMP)
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
1 F1R844 (/IMP)
Sensory perception of smell GO:0007608
The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.
1 Q9U969 (/IMP)
Animal organ morphogenesis GO:0009887
Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.
1 Q3TRM4 (/IMP)
Anterior/posterior axis specification GO:0009948
The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 F1R844 (/IMP)
Negative regulation of BMP signaling pathway GO:0030514
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway.
1 F1R844 (/IMP)
Glial cell apoptotic process GO:0034349
Any apoptotic process in a glial cell, a non-neuronal cell of the nervous system.
1 Q9U969 (/IMP)
Photoreceptor cell maintenance GO:0045494
Any process preventing the degeneration of the photoreceptor, a specialized cell type that is sensitive to light.
1 Q9U969 (/IMP)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
1 Q9U969 (/IDA)
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
1 F1R844 (/IMP)
Neuron apoptotic process GO:0051402
Any apoptotic process in a neuron, the basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.
1 Q9U969 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 Q9U969 (/IDA)
Protein localization to membrane GO:0072657
A process in which a protein is transported to, or maintained in, a specific location in a membrane.
1 Q9U969 (/IMP)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 Q9U969 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
10 B3MRI9 (/ISS) B3NY03 (/ISS) B4H3U8 (/ISS) B4IL64 (/ISS) B4JLX2 (/ISS) B4L535 (/ISS) B4M709 (/ISS) B4N1W9 (/ISS) B4Q0P3 (/ISS) B5DKS8 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
2 A2AJ88 (/TAS) Q8IY17 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9U969 (/IDA)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
1 A2AJ88 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9U969 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9U969 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q8IY17 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q3TRM4 (/ISO)