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CATH Superfamily 2.60.120.10

Jelly Rolls

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54595: Vitamin K-dependent gamma-carboxylase

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Peptidyl-glutamate 4-carboxylase. [EC: 4.1.1.90]
[Peptidyl]-4-carboxyglutamate + 2,3-epoxyphylloquinone + H(2)O = [peptidyl]-glutamate + CO(2) + O(2) + phylloquinol.
  • The enzyme can use various vitamin-K derivatives, including menaquinol, but does not contain iron.
  • The mechanism appears to involve the generation of a strong base by oxygenation of vitamin K.
  • It catalyzes the post-translational carboxylation of glutamate residues of several proteins of the blood-clotting system.
  • 9-12 glutamate residues are converted to 4-carboxyglutamate (Gla) in a specific domain of the target protein.
  • The 4-pro-S hydrogen of the glutamate residue is removed and there is an inversion of stereochemistry at this position.
 5 O88496 P38435 Q07175 Q5RF50 Q9GL59