The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 8705: Chromo domain-containing protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O42934 (/IPI) P40381 (/IPI)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 P40381 (/IDA)
Nucleosomal DNA binding GO:0031492
Interacting selectively and non-covalently with the DNA portion of a nucleosome.
1 P40381 (/IDA)
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
1 P40381 (/IDA)
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
1 P40381 (/IPI)
Nucleosomal histone binding GO:0031493
Interacting selectively and non-covalently with a histone that is assembled into a nucleosome.
1 O42934 (/NAS)
Methylated histone binding GO:0035064
Interacting selectively and non-covalently with a histone protein in which a residue has been modified by methylation. Histones are any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes.
1 P40381 (/IDA)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
2 O42934 (/NAS) P40381 (/NAS)
Chromatin silencing at telomere GO:0006348
Repression of transcription of telomeric DNA by altering the structure of chromatin.
2 O42934 (/IMP) P40381 (/IMP)
Chromatin silencing at silent mating-type cassette GO:0030466
Repression of transcription at silent mating-type loci by alteration of the structure of chromatin.
2 O42934 (/IMP) P40381 (/IMP)
Chromatin silencing at centromere GO:0030702
Repression of transcription of centromeric DNA by altering the structure of chromatin.
2 O42934 (/IMP) P40381 (/IMP)
Mitotic sister chromatid segregation GO:0000070
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
1 P40381 (/IMP)
Chromatin silencing at rDNA GO:0000183
Repression of transcription of ribosomal DNA by altering the structure of chromatin.
1 O42934 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 P40381 (/IMP)
Mitotic sister chromatid cohesion GO:0007064
The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.
1 P40381 (/IGI)
Mating type switching GO:0007533
The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus.
1 P40381 (/IMP)
Gene conversion at mating-type locus GO:0007534
The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged.
1 P40381 (/IMP)
Donor selection GO:0007535
The process that determines which donor locus a cell uses, in preference to another, in mating type switching.
1 P40381 (/IMP)
Cellular protein localization GO:0034613
Any process in which a protein is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
1 P40381 (/IMP)
Chromosome passenger complex localization to kinetochore GO:0072356
A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis.
1 P40381 (/NAS)
Chromatin silencing at centromere outer repeat region GO:1990141
Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin.
1 P40381 (/IMP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear pericentric heterochromatin GO:0031618
Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
2 O42934 (/IDA) P40381 (/IDA)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
2 O42934 (/IDA) P40381 (/IDA)
Condensed nuclear chromosome, centromeric region GO:0000780
The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
1 P40381 (/IDA)
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
1 P40381 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O42934 (/IDA)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
1 P40381 (/IDA)
Pericentric heterochromatin GO:0005721
Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3.
1 P40381 (/IDA)
Mating-type region heterochromatin GO:0031934
Heterochromatic regions of the chromosome found at silenced mating-type loci.
1 P40381 (/IDA)
Mating-type region heterochromatin GO:0031934
Heterochromatic regions of the chromosome found at silenced mating-type loci.
1 O42934 (/TAS)
Chromosome, centromeric outer repeat region GO:0034507
The portion of the centromeric region of a chromosome that flanks the core region, encompassing repeated regions of a chromosome centromere and the proteins that bind to it.
1 P40381 (/IDA)
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
1 P40381 (/IDA)
Nuclear subtelomeric heterochromatin GO:1990707
Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus.
1 O42934 (/TAS)