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CATH Superfamily 2.40.50.140

Nucleic acid-binding proteins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 54148: Aspartate--tRNA(Asp/Asn) ligase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate--tRNA ligase. [EC: 6.1.1.12]
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
    		 186 A0A062V1Q9 A0A062V1Q9 A0A075WCS1 A0A075WCS1 A0A090I4Q7 A0A090I4Q7 A0A0E3H8K7 A0A0E3H8K7 A0A0E3LCU2 A0A0E3LCU2
    (176 more...)
    Aspartate--tRNA(Asn) ligase. [EC: 6.1.1.23]
    ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx).
    • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
    • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
    • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
    		 96 A0A075WCS1 A0A075WCS1 A0A0E3H8K7 A0A0E3H8K7 A0A0E3LCU2 A0A0E3LCU2 A0A0E3LL82 A0A0E3LL82 A0A0E3LU09 A0A0E3LU09
    (86 more...)
    Asparagine--tRNA ligase. [EC: 6.1.1.22]
    ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl- tRNA(Asn).
      		 8 A0A162FJ11 A0A162FJ11 A0A166AMK1 A0A166AMK1 A0A166D181 A0A166D181 A0A166E1Z3 A0A166E1Z3