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CATH Superfamily 2.40.50.140

Nucleic acid-binding proteins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 53549: Aspartate--tRNA(Asp/Asn) ligase

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate--tRNA ligase. [EC: 6.1.1.12]
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
    		 792 A0A024BWQ7 A0A024BWQ7 A0A024C7A0 A0A024C7A0 A0A059HWH5 A0A059HWH5 A0A059HWU1 A0A059HWU1 A0A068N6T5 A0A068N6T5
    (782 more...)
    Aspartate--tRNA(Asn) ligase. [EC: 6.1.1.23]
    ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx).
    • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
    • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
    • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
    		 196 A0A068N6T5 A0A068N6T5 A0A089QV59 A0A089QV59 A0A099UCF6 A0A099UCF6 A0A0A2BI23 A0A0A2BI23 A0A0A2BK99 A0A0A2BK99
    (186 more...)
    Asparagine--tRNA ligase. [EC: 6.1.1.22]
    ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl- tRNA(Asn).
      		 2 A0A0T6A7I5 A0A0T6A7I5