View in Gene3D

CATH Superfamily 2.40.50.140

Nucleic acid-binding proteins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 53145: Transcriptional accessory protein Tex

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Polyribonucleotide nucleotidyltransferase. [EC: 2.7.7.8]
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.
  • ADP, IDP, GDP, UDP and CDP can act as donors.
 68 A0A066RLZ6 A0A066RLZ6 A0A0A0FK51 A0A0A0FK51 A0A0A0HEV9 A0A0A0HEV9 A0A0E2Z3I9 A0A0E2Z3I9 A0A0M7N7N7 A0A0M7N7N7
(58 more...)
Ribonuclease E. [EC: 3.1.26.12]
Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
  • RNase E is a bacterial ribonuclease that plays a role in the processing of ribosomal RNA (9S to 5S rRNA), the chemical degradation of bulk cellular RNA, the decay of specific regulatory, messenger and structural RNAs and the control of plasmid DNA replication.
  • The enzyme binds to monophosphorylated 5' ends of substrates but exhibits sequential cleavages in the 3' to 5' direction.
  • 2'-O-methyl nucleotide substitutions at RNase E binding sites do not prevent binding but do prevent cleavage of non-modified target sequences 5' to that locus.
  • In Escherichia coli, the enzyme is found in the RNA degradosome.
  • The C-terminal half of the protein contains binding sites for the three other major degradosomal components, the DEAD-box RNA helicase Rh1B, EC 4.1.1.11 and EC 2.7.7.8.
  • Formerly EC 3.1.26.n1.
 2 C4WG77 C4WG77