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CATH Superfamily 2.40.50.140

Nucleic acid-binding proteins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Nucleic acid-binding proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 53103: Related to aspartate--tRNA ligase, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aspartate--tRNA ligase. [EC: 6.1.1.12]
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
    		 646 A0A017HD49 A0A017HV53 A0A021X7Z9 A0A024INM8 A0A024KFS5 A0A024LRW3 A0A031HJB9 A0A031JK05 A0A031K5P7 A0A037UQY9
    (636 more...)
    Aspartate--tRNA(Asn) ligase. [EC: 6.1.1.23]
    ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx).
    • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
    • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
    • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
    • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
    • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
    		 165 A0A017HD49 A0A017HV53 A0A024KFS5 A0A059FB62 A0A060Q9U3 A0A060QG86 A0A061MMV9 A0A071I7P5 A0A083ZR68 A0A086PAH3
    (155 more...)
    Asparagine--tRNA ligase. [EC: 6.1.1.22]
    ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl- tRNA(Asn).
      		 26 A0A090E250 A0A090E538 A0A090ESB4 A0A090F6M8 A0A090G6G3 A0A090GIE3 A0A098RWD4 A0A0D6SKG4 A0A0G0N9A8 A0A0G1MWS9
      (16 more...)
      Chenodeoxycholoyltaurine hydrolase. [EC: 3.5.1.74]
      Chenodeoxycholoyltaurine + H(2)O = chenodeoxycholate + taurine.
      • Some other taurine conjugates are hydrolyzed, but not glycine conjugates of bile acids.
      		 21 A0A0E1X1G6 A0A0M1WE01 A0A0M2Y4C4 A0A1L5N817 A5VPT5 A9MAD3 B0CL77 B2S501 C0G5L8 C0RI89
      (11 more...)