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CATH Superfamily 2.40.30.10

Translation factors

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Translation factors
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Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 37476: NAD(P)H-flavin reductase

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Aquacobalamin reductase. [EC: 1.16.1.3]
2 cob(II)alamin + NAD(+) + 2 H(2)O = 2 aquacob(III)alamin + NADH.
  • Formerly EC 1.6.99.8.
 64 A0A061PRM1 A0A061Q8G7 A0A066UTZ0 A0A084TG36 A0A086WI98 A0A087IF58 A0A099MAP3 A0A0A0SKY6 A0A0A3EPS8 A0A0A3VDH6
(54 more...)
Transferred entry: 1.5.1.38, 1.5.1.39 and 1.5.1.41. [EC: 1.5.1.29]
    		9 A0A0E4C404 A0A0H3AHE8 A0A0H3QCM9 A0A0H6VXG4 A0A0K9UNH2 A0A0X1L4Y7 C3LQR7 D0IMY7 Q9KV46
    Riboflavin reductase (NAD(P)H). [EC: 1.5.1.41]
    Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H.
    • Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides.
    • Highest activity with riboflavin.
    • When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin.
    • When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD.
    • Formerly EC 1.5.1.29 and EC 1.6.8.1.
    		 4 A0A1B1NJT1 A0A1C7FD47 A0A1E3WSN1 F9RM94
    Flavin reductase (NADPH). [EC: 1.5.1.30]
    Reduced riboflavin + NADP(+) = riboflavin + NADPH.
    • The enzyme from Entamoeba histolytica reduces riboflavin and galactoflavin, and, more slowly, FMN and FAD.
    • NADH is oxidized more slowly than NADPH.
    • Formerly EC 1.6.8.2.
    		 2 A0A1B9PAC8 B5FF93
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