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CATH Superfamily 2.40.290.10

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1142: ATP-dependent DNA helicase II subunit 2

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
DNA helicase. [EC: 3.6.4.12]
ATP + H(2)O = ADP + phosphate.
  • DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA.
  • Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15).
  • Some helicases unwind DNA as well as RNA (4,9).
  • May be identical with EC 3.6.4.13 (RNA helicase).
 222 A0A010RRQ1 A0A017SMC2 A0A023W0L8 A0A024SJE1 A0A063BQ75 A0A066WYU6 A0A072P0L4 A0A074VQD2 A0A074WER7 A0A074XZS3
(212 more...)
CTP synthase (glutamine hydrolyzing). [EC: 6.3.4.2]
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
  • The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2), and the active site where CTP synthesis takes place.
  • The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP.
  • Ammonia then reacts with this intermediate generating CTP and a phosphate.
  • The enzyme can also use ammonia from the surrounding solution.
 2 A0A0L1JAV3 A0A1F7ZK62
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