The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Plasminogen Kringle 4
".
FunFam 397: Tyrosine-protein kinase transmembrane receptor
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 5 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
|
2 | Q01973 (/TAS) Q9Z139 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q01973 (/IPI) |
|
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
1 | Q01973 (/IPI) |
|
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
1 | Q9Z139 (/ISO) |
|
Coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway GO:1904929
Any coreceptor activity that is involved in Wnt signaling pathway, planar cell polarity pathway.
|
1 | Q01973 (/TAS) |
There are 2 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q01973 (/TAS) |
|
Astrocyte development GO:0014002
The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.
|
1 | D3ZZ97 (/IDA) |
There are 9 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Stress fiber GO:0001725
A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.
|
1 | D3ZZ97 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | D3ZZ97 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q01973 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q01973 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9Z139 (/ISS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q01973 (/TAS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | D3ZZ97 (/IDA) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q01973 (/IDA) |
|
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
|
1 | Q9Z139 (/ISO) |