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CATH Superfamily 2.40.20.10

Plasminogen Kringle 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Plasminogen Kringle 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1676: Tyrosine-protein kinase transmembrane receptor

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Plasmin. [EC: 3.4.21.7]
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
  • Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.14.
 190 A0A087XAX0 A0A087XAX0 A0A087XAX0 A0A087XAX0 A0A087XAX0 A0A096LUY1 A0A096LUY1 A0A096LUY1 A0A096LUY1 A0A096LUY1
(180 more...)
Thrombin. [EC: 3.4.21.5]
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
  • More selective than trypsin and plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.13.
 60 A0A060VM28 A0A060VXZ0 A0A087QYL6 A0A087VGX7 A0A087XJA5 A0A091FQK0 A0A091GNY2 A0A091GSQ4 A0A091JRF9 A0A091JYY1
(50 more...)
Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
 16 A0A0L8IFA9 A0A0L8IFB3 A0A0L8IFB3 A0A0L8IFC2 A0A0L8IFC2 A0A0L8IFF5 A0A0L8IFI2 A0A0L8IFI2 A0A0L8IGP2 A0A0L8IGP2
(6 more...)
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