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CATH Superfamily 2.40.110.10

Butyryl-CoA Dehydrogenase, subunit A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Butyryl-CoA Dehydrogenase, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14373: Probable glutaryl-CoA dehydrogenase, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Glutaryl-CoA dehydrogenase (ETF). [EC: 1.3.8.6]
Glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO(2) + reduced electron-transfer flavoprotein.
  • The enzyme catalyzes the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 4.1.1.70).
  • FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle.
  • The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyzes the oxidation to glutaconyl-CoA (EC 1.3.99.32).
  • Formerly EC 1.3.99.7.
 1036 A0A017HDL0 A0A017HDL0 A0A017HTP5 A0A017HTP5 A0A024HPX3 A0A024HPX3 A0A024J335 A0A024J335 A0A024R7F9 A0A024R7F9
(1026 more...)
Short-chain acyl-CoA dehydrogenase. [EC: 1.3.8.1]
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms.
  • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
  • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
  • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA.
  • Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.1 and EC 1.3.99.2.
 210 A0A045HSS0 A0A045HSS0 A0A063TY60 A0A063TY60 A0A072ZR91 A0A072ZR91 A0A076K058 A0A076K058 A0A083WH57 A0A083WH57
(200 more...)
Transferred entry: 1.3.8.6. [EC: 1.3.99.7]
    		206 A0A031HR80 A0A031HR80 A0A063TY60 A0A063TY60 A0A077M1H4 A0A077M1H4 A0A077M980 A0A077M980 A0A095DN81 A0A095DN81
    (196 more...)
    Acyl-CoA oxidase. [EC: 1.3.3.6]
    Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
    • Acts on CoA derivatives of fatty acids with chain length from C(8) to C(18).
    		 4 A0A0B2PRN0 A0A0B2PRN0 Q96329 Q96329