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CATH Superfamily 2.40.110.10

Butyryl-CoA Dehydrogenase, subunit A, domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Butyryl-CoA Dehydrogenase, subunit A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 14366: Acyl-CoA dehydrogenase, short-chain specific

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Short-chain acyl-CoA dehydrogenase. [EC: 1.3.8.1]
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R-hydrogen atoms.
  • The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms.
  • The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA.
  • The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA.
  • Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.1 and EC 1.3.99.2.
 146 A0A045JGW2 A0A068NFK9 A0A0A8X880 A0A0B0HM32 A0A0B5QW08 A0A0B5SHQ7 A0A0B5X5M7 A0A0C5CKM7 A0A0D0EQR4 A0A0D0ERX4
(136 more...)
Medium-chain acyl-CoA dehydrogenase. [EC: 1.3.8.7]
A medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
  • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
  • The enzyme from pig liver can accept substrates with acyl chain lengths of 4 to 16 carbon atoms, but is most active with C(8) to C(12) compounds.
  • The enzyme from rat does not accept C(16) at all and is most active with C(6)-C(8) compounds.
  • cf. EC 1.3.8.1, EC 1.3.8.8 and EC 1.3.8.9.
  • Formerly EC 1.3.2.2 and EC 1.3.99.3.
 2 A0A0F5RLZ6 A0A1J9U9B5
Transferred entry: 1.3.8.7, 1.3.8.8 and 1.3.8.9. [EC: 1.3.99.3]
    		1 I0JQ65
    Very-long-chain acyl-CoA dehydrogenase. [EC: 1.3.8.9]
    A very-long-chain acyl-CoA + electron-transfer flavoprotein = a very- long-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
    • One of several enzymes that catalyze the first step in fatty acids beta-oxidation.
    • The enzyme is most active toward long-chain acyl-CoAs such as C(14), C(16) and C(18), but is also active with very-long-chain acyl-CoAs up to 24 carbons.
    • It shows no activity for substrates of less than 12 carbons.
    • It's specific activity toward palmitoyl-CoA is more than 10-fold that of the long-chain acyl-CoA dehydrogenase.
    • cf. EC 1.3.8.1, EC 1.3.8.7 and EC 1.3.8.8.
    • Formerly EC 1.3.99.3.
    		 1 A0A0H4PK42