The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5425: Lnk, isoform F

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transducer activity GO:0004871
Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
4 A0A0B4LHS0 (/NAS) A0A0B4LHY5 (/NAS) A0A0B4LIP5 (/NAS) Q7K137 (/NAS)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
4 A0A0B4LHS0 (/NAS) A0A0B4LHY5 (/NAS) A0A0B4LIP5 (/NAS) Q7K137 (/NAS)
TORC1 signaling GO:0038202
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
4 A0A0B4LHS0 (/IMP) A0A0B4LHY5 (/IMP) A0A0B4LIP5 (/IMP) Q7K137 (/IMP)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
4 A0A0B4LHS0 (/IMP) A0A0B4LHY5 (/IMP) A0A0B4LIP5 (/IMP) Q7K137 (/IMP)
Positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568
Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling.
4 A0A0B4LHS0 (/IMP) A0A0B4LHY5 (/IMP) A0A0B4LIP5 (/IMP) Q7K137 (/IMP)
Positive regulation of insulin receptor signaling pathway GO:0046628
Any process that increases the frequency, rate or extent of insulin receptor signaling.
4 A0A0B4LHS0 (/IMP) A0A0B4LHY5 (/IMP) A0A0B4LIP5 (/IMP) Q7K137 (/IMP)
Female mating behavior GO:0060180
The specific behavior of a female organism that is associated with reproduction.
4 A0A0B4LHS0 (/IMP) A0A0B4LHY5 (/IMP) A0A0B4LIP5 (/IMP) Q7K137 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A0B4LHS0 (/IDA) A0A0B4LHY5 (/IDA) A0A0B4LIP5 (/IDA) Q7K137 (/IDA)