The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22383: Pleckstrin homology domain-containing family A mem...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Phosphatidylinositol-5-phosphate binding GO:0010314
Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position.
5 A0A0N4SUU0 (/IDA) A0A0N4SUV0 (/IDA) A0A0N4SW19 (/IDA) A0A0N4SWD7 (/IDA) E9Q6H8 (/IDA)
Phosphatidylinositol-3-phosphate binding GO:0032266
Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.
5 A0A0N4SUU0 (/IDA) A0A0N4SUV0 (/IDA) A0A0N4SW19 (/IDA) A0A0N4SWD7 (/IDA) E9Q6H8 (/IDA)
Phosphatidylinositol-4-phosphate binding GO:0070273
Interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.
5 A0A0N4SUU0 (/IDA) A0A0N4SUV0 (/IDA) A0A0N4SW19 (/IDA) A0A0N4SWD7 (/IDA) E9Q6H8 (/IDA)
Phosphatidylinositol-3,5-bisphosphate binding GO:0080025
Interacting selectively and non-covalently with phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions.
5 A0A0N4SUU0 (/IDA) A0A0N4SUV0 (/IDA) A0A0N4SW19 (/IDA) A0A0N4SWD7 (/IDA) E9Q6H8 (/IDA)
1-phosphatidylinositol binding GO:0005545
Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
2 Q9H4M7 (/NAS) Q9HAU0 (/NAS)
Delta-catenin binding GO:0070097
Interacting selectively and non-covalently with the delta subunit of the catenin complex.
2 B6RSP1 (/ISS) Q3UIL6 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9HAU0 (/IPI)
Delta-catenin binding GO:0070097
Interacting selectively and non-covalently with the delta subunit of the catenin complex.
1 Q6IQ23 (/IDA)
Delta-catenin binding GO:0070097
Interacting selectively and non-covalently with the delta subunit of the catenin complex.
1 Q3UIL6 (/ISO)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Reproductive system development GO:0061458
The progression of the reproductive system over time from its formation to the mature structure. The reproductive system consists of the organs that function in reproduction.
5 A0A0N4SUU0 (/IGI) A0A0N4SUV0 (/IGI) A0A0N4SW19 (/IGI) A0A0N4SWD7 (/IGI) E9Q6H8 (/IGI)
Zonula adherens maintenance GO:0045218
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
2 B6RSP1 (/ISS) Q3UIL6 (/ISS)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
2 B6RSP1 (/ISS) Q3UIL6 (/ISS)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
1 Q9H4M7 (/TAS)
Regulation of heart contraction GO:0008016
Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.
1 B6RSP1 (/IMP)
Zonula adherens maintenance GO:0045218
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
1 Q6IQ23 (/IMP)
Zonula adherens maintenance GO:0045218
Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells.
1 Q3UIL6 (/ISO)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 B6RSP1 (/IMP)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
1 Q6IQ23 (/IMP)
Epithelial cell-cell adhesion GO:0090136
The attachment of an epithelial cell to another epithelial cell via adhesion molecules.
1 Q3UIL6 (/ISO)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
10 A0A024RAY7 (/IDA) A0A0N4SUU0 (/IDA) A0A0N4SUV0 (/IDA) A0A0N4SW19 (/IDA) A0A0N4SWD7 (/IDA) B4DJX4 (/IDA) E9PKC0 (/IDA) E9Q6H8 (/IDA) Q6IQ23 (/IDA) Q9HAU0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A0A0N4SUU0 (/ISO) A0A0N4SUV0 (/ISO) A0A0N4SW19 (/ISO) A0A0N4SWD7 (/ISO) E9Q6H8 (/ISO) Q3UIL6 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
5 A0A0N4SUU0 (/ISO) A0A0N4SUV0 (/ISO) A0A0N4SW19 (/ISO) A0A0N4SWD7 (/ISO) E9Q6H8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
5 A0A0N4SUU0 (/ISO) A0A0N4SUV0 (/ISO) A0A0N4SW19 (/ISO) A0A0N4SWD7 (/ISO) E9Q6H8 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
3 A0A024RAY7 (/IDA) B4DJX4 (/IDA) Q9HAU0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 E9PKC0 (/IDA) Q6IQ23 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 B6RSP1 (/ISS) Q3UIL6 (/ISS)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
2 B6RSP1 (/ISS) Q3UIL6 (/ISS)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
2 E9PKC0 (/IDA) Q6IQ23 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q3UIL6 (/ISO)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q6IQ23 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
1 Q3UIL6 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9H4M7 (/TAS)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
1 Q6IQ23 (/IDA)
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
1 Q3UIL6 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9HAU0 (/IDA)
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
1 Q3UIL6 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q6IQ23 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q3UIL6 (/ISO)