CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 22192: Oxysterol-binding protein-related protein 6
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
5 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) Q9DBS9 (/ISO) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q9BZF2 (/IPI) Q9BZF3 (/IPI) Q9H4L5 (/IPI) |
|
Sterol transporter activity GO:0015248
Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
3 | Q9BZF2 (/TAS) Q9BZF3 (/TAS) Q9H4L5 (/TAS) |
|
Cholesterol binding GO:0015485
Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
|
2 | Q9BZF2 (/IDA) Q9H4L5 (/IDA) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
4 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
4 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) |
|
Bile acid biosynthetic process GO:0006699
The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile.
|
3 | Q9BZF2 (/TAS) Q9BZF3 (/TAS) Q9H4L5 (/TAS) |
|
Regulation of autophagy GO:0010506
Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | Q9BZF2 (/NAS) |
|
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
|
1 | Q9BZF2 (/IMP) |
|
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
|
1 | Q9BZF2 (/IMP) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
6 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) Q8BXR9 (/ISO) Q9DBS9 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) Q8BXR9 (/ISO) Q9DBS9 (/ISO) |
|
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
|
6 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) Q8BXR9 (/ISO) Q9DBS9 (/ISO) |
|
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
|
4 | A2A716 (/ISO) F8VQM4 (/ISO) Q3TAX1 (/ISO) Q5U471 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q9BZF2 (/IDA) Q9BZF3 (/IDA) Q9H4L5 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q9BZF2 (/TAS) Q9BZF3 (/TAS) Q9H4L5 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q9BZF2 (/IDA) Q9BZF3 (/IDA) Q9H4L5 (/IDA) |
|
Perinuclear endoplasmic reticulum GO:0097038
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.
|
3 | Q9BZF2 (/IDA) Q9BZF3 (/IDA) Q9H4L5 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | Q9BZF3 (/IDA) Q9H4L5 (/IDA) |
|
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
|
2 | Q8BXR9 (/ISO) Q9DBS9 (/ISO) |
|
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy.
|
1 | Q9BZF2 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9H4L5 (/IDA) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9DBS9 (/ISO) |