The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 10554: Rho kinase, isoform D

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q961D4 (/ISS) Q9U779 (/ISS) Q9VXE3 (/ISS) X2JE40 (/ISS) X2JKQ8 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
5 Q961D4 (/NAS) Q9U779 (/NAS) Q9VXE3 (/NAS) X2JE40 (/NAS) X2JKQ8 (/NAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 Q961D4 (/IPI) Q9U779 (/IPI) Q9VXE3 (/IPI) X2JE40 (/IPI) X2JKQ8 (/IPI)
GTPase binding GO:0051020
Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP.
5 Q961D4 (/IPI) Q9U779 (/IPI) Q9VXE3 (/IPI) X2JE40 (/IPI) X2JKQ8 (/IPI)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitotic spindle elongation GO:0000022
The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
5 Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
5 Q961D4 (/TAS) Q9U779 (/TAS) Q9VXE3 (/TAS) X2JE40 (/TAS) X2JKQ8 (/TAS)
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Apical constriction involved in gastrulation GO:0003384
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
5 Q961D4 (/NAS) Q9U779 (/NAS) Q9VXE3 (/NAS) X2JE40 (/NAS) X2JKQ8 (/NAS)
Rho protein signal transduction GO:0007266
A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
5 Q961D4 (/IPI) Q9U779 (/IPI) Q9VXE3 (/IPI) X2JE40 (/IPI) X2JKQ8 (/IPI)
Ovarian nurse cell to oocyte transport GO:0007300
Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Nurse cell nucleus anchoring GO:0007302
Attachment of the nurse cell nucleus to the plasma membrane.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Oocyte axis specification GO:0007309
The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
5 Q961D4 (/TAS) Q9U779 (/TAS) Q9VXE3 (/TAS) X2JE40 (/TAS) X2JKQ8 (/TAS)
Female germline ring canal stabilization GO:0008335
Maintenance of the structural integrity of the ring canals connecting the female germline cyst.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of cell shape GO:0008360
Any process that modulates the surface configuration of a cell.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Ommatidial rotation GO:0016318
The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification.
5 Q961D4 (/NAS) Q9U779 (/NAS) Q9VXE3 (/NAS) X2JE40 (/NAS) X2JKQ8 (/NAS)
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Actin cytoskeleton reorganization GO:0031532
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Cortical protein anchoring GO:0032065
A process in which a protein or protein complex is maintained in a specific location in the cell cortex.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of actin filament bundle assembly GO:0032231
Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Regulation of actin filament bundle assembly GO:0032231
Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Nuclear axial expansion GO:0035191
The stepwise asymmetric spreading out of nuclei internally along the anterior-posterior axis of the developing insect embryo during mitotic cycles 4 to 6. This movement leads to the distribution of nuclei in a hollow ellipsoid underlying the cortex.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
5 Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Oocyte development GO:0048599
The process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of axonogenesis GO:0050770
Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Positive regulation of wound healing GO:0090303
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Regulation of cell junction assembly GO:1901888
Any process that modulates the frequency, rate or extent of cell junction assembly.
5 Q961D4 (/IGI) Q9U779 (/IGI) Q9VXE3 (/IGI) X2JE40 (/IGI) X2JKQ8 (/IGI)
Negative regulation of response to wounding GO:1903035
Any process that stops, prevents or reduces the frequency, rate or extent of response to wounding.
5 Q961D4 (/IMP) Q9U779 (/IMP) Q9VXE3 (/IMP) X2JE40 (/IMP) X2JKQ8 (/IMP)
Regulation of planar cell polarity pathway involved in axis elongation GO:2000040
Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation.
5 Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell-cell contact zone GO:0044291
Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
5 Q961D4 (/IDA) Q9U779 (/IDA) Q9VXE3 (/IDA) X2JE40 (/IDA) X2JKQ8 (/IDA)