View in Gene3D

CATH Superfamily 2.30.130.10

PUA domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
PUA domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4887: tRNA pseudouridine synthase B

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
TRNA pseudouridine(55) synthase. [EC: 5.4.99.25]
tRNA uridine(55) = tRNA pseudouridine(55).
  • Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules.
  • The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54).
  • It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
 2941 A0A009KA20 A0A009L7G4 A0A009ZHV5 A0A010SMJ0 A0A011NBS5 A0A011NS55 A0A011PK97 A0A011PMV5 A0A011Q4U8 A0A011Q622
(2931 more...)
Pseudouridylate synthase. [EC: 4.2.1.70]
Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.
  • The reaction it readily reversible.
  • While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.
 15 A0A090P522 A0A090QUX8 A0A090SJQ1 A0A090T259 A0A0B8PXM2 A0A160TAZ9 A0A160TWW6 A0A1L6FDP0 A0A1L6KB76 A0A1L9F479
(5 more...)
TRNA pseudouridine(38-40) synthase. [EC: 5.4.99.12]
tRNA uridine(38-40) = tRNA pseudouridine(38-40).
  • The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine.
  • TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures.
 2 A0A1L9F479 K2B7J4
CATH-Gene3D is a Global Biodata Core Resource Learn more...