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CATH Superfamily 2.20.140.10

WGR domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
WGR domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 671: Poly [ADP-ribose] polymerase 1

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
NAD(+) ADP-ribosyltransferase. [EC: 2.4.2.30]
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
  • The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
 1501 A0A010R3N3 A0A014PFX3 A0A014QVK2 A0A015K5T5 A0A016TMN1 A0A016TNB2 A0A016W4D6 A0A016W4I9 A0A016WWB5 A0A016WWR2
(1491 more...)
NAD(+)--protein-arginine ADP-ribosyltransferase. [EC: 2.4.2.31]
NAD(+) + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)- protein-L-arginine.
  • Arginine residues in proteins act as acceptors.
  • Free arginine, agmatine ((4-aminobutyl)guanidine), arginine methyl ester and guanidine can also do so.
  • Catalyzes the NAD(+)-dependent activation of EC 4.6.1.1.
  • Some bacterial enterotoxins possess similar enzymatic activities (cf. EC 2.4.2.36).
 5 A0A024TTZ3 A0A024U7C5 A0A0S4IPV1 T0Q1P2 W4FY19