The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Thrombospondin type-1 (TSP1) repeat
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9794: Semaphorin 5A isoform A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Chondroitin sulfate proteoglycan binding GO:0035373
Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.
2 Q13591 (/ISS) Q62217 (/ISS)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
2 Q13591 (/ISS) Q62217 (/ISS)
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
2 Q13591 (/ISS) Q62217 (/ISS)
Axon guidance receptor activity GO:0008046
Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
1 Q62217 (/IDA)
Semaphorin receptor binding GO:0030215
Interacting selectively and non-covalently with semaphorin receptors.
1 Q62217 (/IPI)
Chondroitin sulfate proteoglycan binding GO:0035373
Interacting selectively and non-covalently with a chondroitin sulfate proteoglycan, any proteoglycan containing chondroitin sulfate as the glycosaminoglycan carbohydrate unit.
1 D3ZTD8 (/IMP)
Heparan sulfate proteoglycan binding GO:0043395
Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit.
1 D3ZTD8 (/IMP)
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
1 D3ZTD8 (/IPI)

There are 49 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
4 A0A0R4IMM9 (/IGI) F1R9L1 (/IGI) Q60519 (/IGI) Q62217 (/IGI)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
2 Q13591 (/ISS) Q62217 (/ISS)
Diencephalon development GO:0021536
The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
2 Q13591 (/ISS) Q62217 (/ISS)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Positive regulation of catenin import into nucleus GO:0035413
Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
2 A0A0R4IMM9 (/IMP) F1R9L1 (/IMP)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
2 Q13591 (/ISS) Q62217 (/ISS)
Negative regulation of axon extension involved in axon guidance GO:0048843
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
2 Q13591 (/ISS) Q62217 (/ISS)
Detection of light stimulus involved in visual perception GO:0050908
The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal.
2 Q60519 (/IGI) Q62217 (/IGI)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
2 Q60519 (/IGI) Q62217 (/IGI)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q60519 (/IDA) Q62217 (/IDA)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q60519 (/IGI) Q62217 (/IGI)
Signal clustering GO:1990256
Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Positive regulation of endothelial cell chemotaxis GO:2001028
Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
2 D3ZTD8 (/ISS) Q13591 (/ISS)
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
1 Q62217 (/IMP)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
1 Q62217 (/IDA)
Blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043
The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis.
1 Q62217 (/IDA)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q13591 (/TAS)
Negative regulation of cell adhesion GO:0007162
Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.
1 Q62217 (/IDA)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q13591 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q13591 (/TAS)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q62217 (/IMP)
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
1 D3ZTD8 (/IDA)
Diencephalon development GO:0021536
The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex.
1 D3ZTD8 (/IMP)
Positive regulation of actin filament depolymerization GO:0030836
Any process that activates or increases the frequency, rate or extent of actin depolymerization.
1 Q62217 (/IDA)
Positive regulation of catenin import into nucleus GO:0035413
Any process that increases the rate, frequency or extent of the directed movement of a catenin protein from the cytoplasm into the nucleus.
1 Q62217 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
1 Q62217 (/IDA)
Branching morphogenesis of an epithelial tube GO:0048754
The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder.
1 Q62217 (/IMP)
Positive regulation of axon extension involved in axon guidance GO:0048842
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance.
1 D3ZTD8 (/IMP)
Negative regulation of axon extension involved in axon guidance GO:0048843
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance.
1 D3ZTD8 (/IMP)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
1 Q62217 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 Q62217 (/IDA)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q62217 (/IDA)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
1 Q62217 (/IDA)
Semaphorin-plexin signaling pathway GO:0071526
A series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand.
1 D3ZTD8 (/ISS)
Positive regulation of extracellular matrix disassembly GO:0090091
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.
1 Q62217 (/NAS)
Neuron projection guidance GO:0097485
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
1 Q60519 (/IMP)
Signal clustering GO:1990256
Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.
1 Q62217 (/IDA)
Signal clustering GO:1990256
Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response.
1 D3ZTD8 (/IMP)
Negative regulation of endothelial cell apoptotic process GO:2000352
Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process.
1 Q62217 (/IDA)
Positive regulation of endothelial cell chemotaxis GO:2001028
Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
1 Q62217 (/IDA)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q13591 (/ISS) Q62217 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q13591 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 D3ZTD8 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q62217 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q13591 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q62217 (/ISO)