The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Thrombospondin type-1 (TSP1) repeat
".
FunFam 10006: ADAMTS-like 3 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
|
8 | E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) P59511 (/IDA) P59511 (/IDA) Q69ZM2 (/IDA) Q8CDB8 (/IDA) |
|
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
6 | E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) Q69ZM2 (/ISO) Q8CDB8 (/ISO) |
|
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
4 | Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9UKP5 (/TAS) |
|
Metallopeptidase activity GO:0008237
Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
3 | Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) |
|
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
2 | P59511 (/IDA) P59511 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P82987 (/IPI) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
11 |
E9PUN6 (/IDA)
E9PUN6 (/IDA)
E9PYV8 (/IDA)
E9PYV8 (/IDA)
P59511 (/IDA)
P59511 (/IDA)
Q69ZM2 (/IDA)
Q8CDB8 (/IDA)
Q9P2N4 (/IDA)
Q9P2N4 (/IDA)
(1 more) |
|
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
|
8 | E9PUN6 (/IGI) E9PUN6 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) P59511 (/IGI) P59511 (/IGI) Q69ZM2 (/IGI) Q8CDB8 (/IGI) |
|
Regulation of developmental pigmentation GO:0048070
Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
|
8 | E9PUN6 (/IGI) E9PUN6 (/IGI) E9PYV8 (/IGI) E9PYV8 (/IGI) P59511 (/IGI) P59511 (/IGI) Q69ZM2 (/IGI) Q8CDB8 (/IGI) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
6 | E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) Q69ZM2 (/ISO) Q8CDB8 (/ISO) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
6 | E7F6N6 (/IMP) E7F6N6 (/IMP) F1R6Q4 (/IMP) F1R6Q4 (/IMP) G3G3K0 (/IMP) G3G3K0 (/IMP) |
|
Pancreas regeneration GO:1990798
The regrowth of a destroyed pancreas.
|
6 | E7F6N6 (/IMP) E7F6N6 (/IMP) F1R6Q4 (/IMP) F1R6Q4 (/IMP) G3G3K0 (/IMP) G3G3K0 (/IMP) |
|
Glycoprotein catabolic process GO:0006516
The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.
|
3 | Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) |
|
Multicellular organism development GO:0007275
The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
|
3 | Q9P2N4 (/TAS) Q9P2N4 (/TAS) Q9P2N4 (/TAS) |
|
Cardiac septum development GO:0003279
The progression of a cardiac septum over time, from its initial formation to the mature structure.
|
2 | D3Z1A5 (/IMP) Q8C9R1 (/IMP) |
|
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | D3Z1A5 (/IMP) Q8C9R1 (/IMP) |
|
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
|
2 | P59511 (/IMP) P59511 (/IMP) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
2 | P59511 (/IDA) P59511 (/IDA) |
|
Aorta development GO:0035904
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.
|
2 | D3Z1A5 (/IMP) Q8C9R1 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P59511 (/IMP) P59511 (/IMP) |
|
Positive regulation of melanocyte differentiation GO:0045636
Any process that activates or increases the frequency, rate or extent of melanocyte differentiation.
|
2 | P59511 (/IMP) P59511 (/IMP) |
|
Regulation of developmental pigmentation GO:0048070
Any process that modulates the frequency, rate or extent of the developmental process that results in the deposition of coloring matter in an organism.
|
2 | P59511 (/IMP) P59511 (/IMP) |
|
Coronary vasculature development GO:0060976
The process whose specific outcome is the progression of the blood vessels of the heart over time, from its formation to the mature structure.
|
2 | D3Z1A5 (/IMP) Q8C9R1 (/IMP) |
|
Protein O-linked fucosylation GO:0036066
The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.
|
1 | Q8N6G6 (/TAS) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
8 | E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) P59511 (/IDA) P59511 (/IDA) Q69ZM2 (/IDA) Q8CDB8 (/IDA) |
|
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
6 | E9PUN6 (/ISO) E9PUN6 (/ISO) E9PYV8 (/ISO) E9PYV8 (/ISO) Q69ZM2 (/ISO) Q8CDB8 (/ISO) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
6 | E9PUN6 (/IDA) E9PUN6 (/IDA) E9PYV8 (/IDA) E9PYV8 (/IDA) Q69ZM2 (/IDA) Q8CDB8 (/IDA) |
|
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
3 | Q9P2N4 (/IDA) Q9P2N4 (/IDA) Q9P2N4 (/IDA) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | Q8N6G6 (/TAS) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | P82987 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | G3UXC7 (/ISO) |