The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Hexapeptide repeat proteins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 82718: Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosami...

There are 7 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase. [EC: 2.3.1.129]
(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D- glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)- N-acetyl-alpha-D-glucosamine.
  • Involved with EC 2.4.1.182 and EC 2.7.1.130 in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
58 A0A0B5BHT7 A0A0C1QXR8 A0A0C2DGA6 A0A0D5NAT0 A0A0E3YW86 A0A0F3INC2 A0A0F7JY36 A0A0G3ECV6 A0A0K3BQF8 A0A0N9I467
(48 more...)
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase. [EC: 2.3.1.191]
(3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-3-O-((3R)- hydroxytetradecanoyl)-alpha-D-glucosamine = UDP-2-N,3-O-bis((3R)-3- hydroxytetradecanoyl)-alpha-D-glucosamine + a holo-[acyl-carrier- protein].
  • The enzyme catalyzes a step of lipid A biosynthesis.
  • LpxD from Escherichia coli prefers (R,S)-3-hydroxymyristoyl-[acyl- carrier protein] over (R,S)-3-hydroxypalmitoyl-[acyl-carrier protein].
  • E.coli lipid A acyltransferases do not have an absolute specificity for 14-carbon hydroxy fatty acids but can transfer fatty acids differing by one carbon unit if the fatty acid substrates are available.
  • When grown on 1% propionic acid, lipid A also contains the odd-chain fatty acids tridecanoic acid, pentadecanoic acid, hydroxytridecanoic acid, and hydroxypentadecanoic acid.
  • Formerly EC 2.3.1.n1.
5 A0A0H6MI19 A0A1K2G825 G8URM7 I4B588 Q5ZY64
UDP-N-acetylbacillosamine N-acetyltransferase. [EC: 2.3.1.203]
Acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP- N,N'-diacetylbacillosamine.
  • The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species and O-linked glycosylation of certain L-serine residues in Neisseria species.
3 A0A076FCU2 A0A0E1GN57 A0A172SQ36
Tetrahydrodipicolinate N-acetyltransferase. [EC: 2.3.1.89]
Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H(2)O = CoA + L-2-acetamido-6-oxoheptanedioate.
    2 A0A156AB52 A0A1C6FS31
    Mannose-1-phosphate guanylyltransferase. [EC: 2.7.7.13]
    GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
    • The bacterial enzyme can also use ITP and dGTP as donors.
    2 A0A0A1VNM2 K9PGA4
    Serine O-acetyltransferase. [EC: 2.3.1.30]
    Acetyl-CoA + L-serine = CoA + O-acetyl-L-serine.
      2 A0A174XE30 A0A1E3U9K0
      Phosphoglucosamine mutase. [EC: 5.4.2.10]
      Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate.
      • The enzyme is involved in the pathway for bacterial cell-wall peptidoglycan and lipopolysaccharide biosyntheses, being an essential step in the pathway for UDP-N-acetylglucosamine biosynthesis.
      • The enzyme from Escherichia coli is activated by phosphorylation and can be autophosphorylated in vitro by alpha-D-glucosamine 1,6- bisphosphate, which is an intermediate in the reaction, alpha-D- glucose 1,6-bisphosphate or ATP.
      • It can also catalyze the interconversion of alpha-D-glucose 1-phosphate and alpha-D-glucose 6-phosphate, although at a much lower rate.
      1 K9PGA4