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CATH Superfamily 2.140.10.30

Dipeptidylpeptidase IV, N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Dipeptidylpeptidase IV, N-terminal domain

Structural domains comprising this superfamily share the structure of the N-terminal beta propeller domain of dipeptidylpeptidase IV, a multifunctional type II transmembrane serine peptidase. This enzyme contributes to the regulation of various physiological processes, including blood sugar homeostasis, by cleaving peptide hormones, chemokines and neuropeptides after a proline or alanine at amino acid position 2 from the N terminus PMID:14718659. Dipeptidylpetidase IV also serves as the costimulatory molecule in T cell activation and is an associated marker of autoimmune diseases, adenosine deaminase-deficiency and HIV pathogenesis PMID:1352530,PMID:20959412,PMID:21856036.

GO Diversity

Unique GO annotations
83 Unique GO terms

EC Diversity

Unique EC annotations
10 Unique EC terms

Species Diversity

Unique species annotations
3729 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 309
Domain clusters (>95% seq id): 9
Domain clusters (>35% seq id): 5
Unique PDBs: 127
Alignments
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 6
Function
Unique EC: 10
Unique GO: 83
Taxonomy
Unique Species: 3729